The Kaposi's sarcoma-associated herpesvirus ORF57 protein and its multiple roles in mRNA biogenesis

Jackson, B. R., Noerenberg, M. and Whitehouse, A. (2012) The Kaposi's sarcoma-associated herpesvirus ORF57 protein and its multiple roles in mRNA biogenesis. Frontiers in Microbiology, 3, 59. (doi: 10.3389/fmicb.2012.00059) (PMID:22363332) (PMCID:PMC3282479)

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Abstract

Post-transcriptional events which regulate mRNA biogenesis are fundamental to the control of gene expression. A nascent mRNA is therefore steered through multimeric RNA–protein complexes that mediate its capping, splicing, polyadenylation, nuclear export, and ultimately its translation. Kaposi’s sarcoma-associated herpesvirus (KSHV) mRNA transport and accumulation protein, or ORF57, is a functionally conserved protein found in all herpesviruses which plays a pivotal role in enhancing viral gene expression at a post-transcriptional level. As such, ORF57 has been implicated in multiple steps of RNA biogenesis, including augmenting viral splicing, protecting viral RNAs from degradation to enhancing viral mRNA nuclear export and translation. In this review, we highlight the multiple roles of KSHV ORF57 in regulating the post-transcriptional events which are fundamental to the control of virus gene expression.

Item Type:Articles
Additional Information:Work discussed herein that was produced by the Whitehouse laboratory was supported by grants from the Biotechnology and Biological Sciences Research Council, Wellcome Trust, Yorkshire Cancer Research, and Leverhulme Trust. Adrian Whitehouse is the recipient of a BBSRC Research Development Fellowship.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Noerenberg, Dr Marko
Authors: Jackson, B. R., Noerenberg, M., and Whitehouse, A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Frontiers in Microbiology
Publisher:Frontiers Media
ISSN:1664-302X
ISSN (Online):1664-302X
Copyright Holders:Copyright © 2012 Jackson, Noerenberg and Whitehouse
First Published:First published in Frontiers in Microbiology 3: 59
Publisher Policy:Reproduced under a Creative Commons License

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