Engineered diets to improve cancer outcomes

Goncalves, M. D. and Maddocks, O. D.K. (2021) Engineered diets to improve cancer outcomes. Current Opinion in Biotechnology, 70, pp. 29-35. (doi: 10.1016/j.copbio.2020.10.007) (PMID:33232844)

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Abstract

Cancer cells acquire a diverse range of metabolic adaptations that support their enhanced rates of growth and proliferation. While these adaptations help tune metabolism to support higher anabolic output and bolster antioxidant defenses, they can also decrease metabolic flexibility and increase dependence on nutrient uptake versus de novo synthesis. Diet is the major source of nutrients that ultimately support tumor growth, yet the potential impact of diet is currently underutilized during the treatment of cancer. Here, we review several forms of dietary augmentation therapy including those that alter the content of food, such as energy or macronutrient restriction, and those that alter the timing of food consumption, like intermittent fasting regimens. We discuss how these dietary strategies can be combined with pharmacologic therapies to exaggerate the metabolic liabilities of different cancer types.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maddocks, Professor Oliver
Authors: Goncalves, M. D., and Maddocks, O. D.K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Current Opinion in Biotechnology
Publisher:Elsevier
ISSN:0958-1669
ISSN (Online):1879-0429
Published Online:21 November 2020
Copyright Holders:Copyright © 2020 Elsevier Ltd.
First Published:First published in Current Opinion in Biotechnology 70:29-35
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
171982Targeting Tumour Metabolism for Cancer Therapy and Diagnosis.Oliver MaddocksCancer Research UK (CRUK)C53309/A19702Institute of Cancer Sciences