Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions

Karcioglu, O., Arnold, J., Topacoglu, H., Ozucelik, D.N., Kiran, S. and Sonmez, N. (2006) Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions. International Journal of Clinical Practice, 60(12), pp. 1638-1646. (doi: 10.1111/j.1742-1241.2005.00685.x) (PMID:17109670)

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Abstract

This meta‐analysis was undertaken to compare the effects of succinylcholine (SCH) and rocuronium (RCR) on endotracheal intubation (ETI) conditions. Eligible randomised controlled trials (RCTs) were identified via medline and a manual search of references. The frequencies of excellent and unacceptable ETI conditions in subjects receiving SCH 1.0–1.5 mg/kg and RCR 0.6–1.2 mg/kg were determined using standard statistical methods. Inclusion criteria were met by 16 RCTs, representing 1362 subjects. SCH was associated with a 17.7% increase (95% CI = 13–22) in the frequency of excellent ETI conditions and a 5.1% decrease (95% CI = −7.3 to −2.9) in the frequency of unacceptable ETI conditions, when compared with RCR. In the subgroup undergoing true rapid sequence intubation, SCH was associated with a 19.1% increase (95% CI = 13.7–24.5) in the frequency of excellent ETI conditions. SCH appears to be superior to RCR in creating excellent ETI conditions and avoiding unacceptable ETI conditions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kiran, Professor Sibel
Authors: Karcioglu, O., Arnold, J., Topacoglu, H., Ozucelik, D.N., Kiran, S., and Sonmez, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:International Journal of Clinical Practice
Publisher:Wiley
ISSN:1368-5031
ISSN (Online):1742-1241
Published Online:10 November 2006

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