Effects of pegylated interferon α on fibrinolytic parameters in patients with chronic hepatitis C

Gokmen, A., Ustundag, Y., Oztoprak, N., Aydemir, S., Tekin, I. O., Cakal, B., Kiran, S. and Engin, H. (2011) Effects of pegylated interferon α on fibrinolytic parameters in patients with chronic hepatitis C. Clinical and Applied Thrombosis/Hemostasis, 17(5), pp. 449-453. (doi: 10.1177/1076029610371475) (PMID:20699259)

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Abstract

Interferon (IFN) interacts with endothelial cells and modulates the functions of these cells. In our study, we aimed to determine the effects of treatment with pegylated IFN-α (peg-IFN-α) on fibrinolytic parameters in patients with chronic hepatitis C. Fifteen patients with chronic hepatitis C were treated with peg-IFN-α once per week plus daily oral ribavirin. Euglobulin lysis time (ELT), plasma levels of d-dimer, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), and thrombin activatable fibrinolysis inhibitor (TAFI) were determined before treatment, 2 weeks, 1 month, and 3 months after the initiation of the treatment. Plasma levels of t-PA increased significantly 1 month and 3 months after the treatment (P < .05). The PAI-1 and TAFI levels in 2 weeks, 1 month and 3 months after treatment were not statistically different as compared with pretreatment levels (P > .05) No significant difference in plasma d-dimer levels was observed during peg-IFN-α treatment (P > .05). There was a significant decrease in ELT 1 month and 3 months after the treatment (P < .05). Our results indicated that treatment with peg-IFN-α may be associated with enhanced fibrinolysis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kiran, Professor Sibel
Authors: Gokmen, A., Ustundag, Y., Oztoprak, N., Aydemir, S., Tekin, I. O., Cakal, B., Kiran, S., and Engin, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Clinical and Applied Thrombosis/Hemostasis
Publisher:SAGE Publications
ISSN:1076-0296
ISSN (Online):1938-2723
Published Online:10 August 2010

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