Characterization of deep sub-wavelength nanowells by imaging the photon state scattering spectra

Liu, W. et al. (2021) Characterization of deep sub-wavelength nanowells by imaging the photon state scattering spectra. Optics Express, 29(2), pp. 1221-1231. (doi: 10.1364/OE.413942)

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Optical-matter interactions and photon scattering in a sub-wavelength space are of great interest in many applications, such as nanopore-based gene sequencing and molecule characterization. Previous studies show that spatial distribution features of the scattering photon states are highly sensitive to the dielectric and structural properties of the nanopore array and matter contained on or within them, as a result of the complex optical-matter interaction in a confined system. In this paper, we report a method for shape characterization of subwavelength nanowells using photon state spatial distribution spectra in the scattering near field. Far-field parametric images of the near-field optical scattering from sub-wavelength nanowell arrays on a SiN substrate were obtained experimentally. Finite-difference time-domain simulations were used to interpret the experimental results. The rich features of the parametric images originating from the interaction of the photons and the nanowells were analyzed to recover the size of the nanowells. Experiments on nanoholes modified with Shp2 proteins were also performed. Results show that the scattering distribution of modified nanoholes exhibits significant differences compared to empty nanoholes. This work highlights the potential of utilizing the photon status scattering of nanowells for molecular characterization or other virus detection applications.

Item Type:Articles
Additional Information:Funding: The National Major Scientific Instruments and Equipment Development Project (Grant No.61827814); National Key Research and Development Program of China (No.2017YFF0107100); Fundamental Research Funds for the Central Universities (30920010011); Natural Science Foundation of Beijing Municipality (Z190018); Engineering and Physical Sciences Research Council (EP/R042578/1); the Ministry of Education collaborative project; Royal Society (Grant IEC/NSFC/181557).
Glasgow Author(s) Enlighten ID:Hou, Dr Lianping and Ye, Dr Shengwei and Marsh, Professor John
Authors: Liu, W., Xiong, J., Zhu, L., Ye, S., Zhao, H., Liu, J., Zhang, H., Hou, L., Marsh, J. H., Dong, L., Gao, X. W., Shi, D., and Liu, X.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Optics Express
Publisher:Optical Society of America
ISSN (Online):1094-4087
Copyright Holders:Copyright © 2021 Optics Express
First Published:First published in Optics Express 29(2):1221-1231
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
302617Optically controlled THz phased array antennasJohn MarshEngineering and Physical Sciences Research Council (EPSRC)EP/R042578/1ENG - Electronics & Nanoscale Engineering