Targeting opposing immunological roles of the junctional adhesion molecule-A in autoimmunity and cancer

Bonilha, C. S., Benson, R. A. , Brewer, J. M. and Garside, P. (2020) Targeting opposing immunological roles of the junctional adhesion molecule-A in autoimmunity and cancer. Frontiers in Immunology, 11, 602094. (doi: 10.3389/fimmu.2020.602094) (PMID:33324419) (PMCID:PMC7723963)

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Abstract

The junctional adhesion molecule-A (JAM-A) is a cell surface adhesion molecule expressed on platelets, epithelial cells, endothelial cells and leukocytes (e. g. monocytes and dendritic cells). JAM-A plays a relevant role in leukocyte trafficking and its therapeutic potential has been studied in several pathological conditions due to its capacity to induce leukocyte migration out of inflamed sites or infiltration into tumor sites. However, disruption of JAM-A pathways may worsen clinical pathology in some cases. As such, the effects of JAM-A manipulation on modulating immune responses in the context of different diseases must be better understood. In this mini-review, we discuss the potential of JAM-A as a therapeutic target, summarizing findings from studies manipulating JAM-A in the context of inflammatory diseases (e.g. autoimmune diseases) and cancer and highlighting described mechanisms.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Garside, Professor Paul and Brewer, Professor James and Benson, Dr Robert and Bonilha, Caio
Authors: Bonilha, C. S., Benson, R. A., Brewer, J. M., and Garside, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Immunology
Publisher:Frontiers Media
ISSN:1664-3224
ISSN (Online):1664-3224
Copyright Holders:Copyright © 2020 Bonilha, Benson, Brewer and Garside
First Published:First published in Frontiers in Immunology 11:602094
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
166480Defining the Role of Cell Migration in the Initiation and Regulation of Pathogenesis in Inflammatory ArthritisPaul GarsideVersus Arthritis (ARTRESUK)MP/19788III - Immunology
303229RACE RenewalIain McInnesVersus Arthritis (ARTRESUK)NW/22072III - Immunology