ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells

Walker, M. , Luo, J., Pringle, E. W. and Cantini, M. (2021) ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells. Materials Science and Engineering C: Materials for Biological Applications, 121, 111822. (doi: 10.1016/j.msec.2020.111822) (PMID:33579465)

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Abstract

The extracellular matrix is a highly complex microenvironment, whose various components converge to regulate cell fate. Hydrogels, as water-swollen polymer networks composed by synthetic or natural materials, are ideal candidates to create biologically active substrates that mimic these matrices and target cell behaviour for a desired tissue engineering application. Indeed, the ability to tune their mechanical, structural, and biochemical properties provides a framework to recapitulate native tissues. This review explores how hydrogels have been engineered to harness the chondrogenic response of stem cells for the repair of damaged cartilage tissue. The signalling processes involved in hydrogel-driven chondrogenesis are also discussed, identifying critical pathways that should be taken into account during hydrogel design.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Pringle, Eonan and Walker, Dr Matthew and Luo, Mr Jiajun and Cantini, Dr Marco
Authors: Walker, M., Luo, J., Pringle, E. W., and Cantini, M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Materials Science and Engineering C: Materials for Biological Applications
Publisher:Elsevier
ISSN:0928-4931
ISSN (Online):1873-0191
Published Online:29 December 2020
Copyright Holders:Copyright © 2020 Elsevier B.V.
First Published:First published in Materials Science and Engineering C: Materials for Biological Applications 121: 111822
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303613Engineered microenvironments to harvest stem cell response to viscosity for cartilage repairMarco CantiniMedical Research Council (MRC)MR/S005412/1ENG - Biomedical Engineering