Milligan, G. , Barki, N. and Tobin, A. (2021) Chemogenetic approaches to explore the functions of Free Fatty Acid Receptor 2. Trends in Pharmacological Sciences, 42(3), pp. 191-202. (doi: 10.1016/j.tips.2020.12.003) (PMID:33495026)
Text
227219.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. 304kB |
Abstract
Short-chain fatty acids are generated in large amounts by the intestinal microbiota. They activate both the closely related G protein-coupled receptors free fatty acid receptor 2 (FFA2) and free fatty acid receptor 3 (FFA3) that are considered therapeutic targets in diseases of immuno-metabolism. Limited and species-selective small-molecule pharmacology has restricted our understanding of the distinct roles of these receptors. Replacement of mouse FFA2 with a designer receptor exclusively activated by designer drug form of human FFA2 (hFFA2-DREADD) has allowed definition of specific roles of FFA2 in pharmacological and physiological studies conducted both ex vivo and in vivo, whilst overlay of murine disease models offers opportunities for therapeutic validation prior to human studies. Similar approaches can potentially be used to define roles of other poorly characterised receptors.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Milligan, Professor Graeme and Tobin, Andrew and Barki, Ms Natasja |
Authors: | Milligan, G., Barki, N., and Tobin, A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Trends in Pharmacological Sciences |
Publisher: | Elsevier (Cell Press) |
ISSN: | 0165-6147 |
ISSN (Online): | 1873-3735 |
Published Online: | 22 January 2021 |
Copyright Holders: | Copyright © 2020 Elsevier |
First Published: | First published in Trends in Pharmacological Sciences 42(3): 191-202 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record