The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer

Barber, M.D., McMillan, D.C., Wallace, A.M., Ross, J.A., Preston, T. and Fearon, K.C.H. (2004) The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer. British Journal of Cancer, 90(6), 1129 -1132. (doi:10.1038/sj.bjc.6601712)

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Publisher's URL: http://dx.doi.org/10.1038/sj.bjc.6601712

Abstract

At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05), but less for leptin in the cancer group (P<0.05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Fearon, Prof Kenneth and Preston, Professor Thomas
Authors: Barber, M.D., McMillan, D.C., Wallace, A.M., Ross, J.A., Preston, T., and Fearon, K.C.H.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:British Journal of Cancer
ISSN:0007-0920

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