Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive Pulmonary disease (COPD)

Short, B. et al. (2021) Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive Pulmonary disease (COPD). Critical Reviews in Microbiology, 47(2), pp. 192-205. (doi: 10.1080/1040841X.2020.1863330) (PMID:33455514)

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Abstract

Haemophilus influenzae is the most common cause of bacterial infection in the lungs of chronic obstructive pulmonary disease (COPD) patients and contributes to episodes of acute exacerbation which are associated with increased hospitalization and mortality. Due to the ability of H. influenzae to adhere to host epithelial cells, initial colonization of the lower airways can progress to a persistent infection and biofilm formation. This is characterized by changes in bacterial behaviour such as reduced cellular metabolism and the production of an obstructive extracellular matrix (ECM). Herein we discuss the multiple mechanisms by which H. influenzae contributes to the pathogenesis of COPD. In particular, mechanisms that facilitate bacterial adherence to host airway epithelial cells, biofilm formation, and microbial persistence through immune system evasion and antibiotic tolerance will be discussed.

Item Type:Articles
Additional Information:This study was funded as part of the Borders and Regions Airways Training Hub project (BREATH; INT-VA/045) by the European Union (EU), under the INTERREG VA Programme, managed by the Special EU Programmes Body (to KDT, SLM, LPMcG, FTL and AC).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Crilly, Dr Anne and MacKay, Mr William and Ramage, Professor Gordon and Williams, Dr Craig
Authors: Short, B., Carson, S., Devlin, A.-C., Reihill, J. A., Crilly, A., MacKay, W., Ramage, G., Williams, C., Lundy, F. T., McGarvey, L. P., Thornbury, K., and Martin, S. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Critical Reviews in Microbiology
Publisher:Taylor & Francis
ISSN:1040-841X
ISSN (Online):1549-7828
Published Online:18 January 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Critical Reviews in Microbiology 47(2):192-205
Publisher Policy:Reproduced under a Creative Commons License

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