Profilin as a potential mediator of membrane-cytoskeleton communication

Machesky, L. M. and Pollard, T. D. (1993) Profilin as a potential mediator of membrane-cytoskeleton communication. Trends in Cell Biology, 3(11), pp. 381-385. (doi: 10.1016/0962-8924(93)90087-h) (PMID:14731655)

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Abstract

Profilin, the prototype actin-monomer-sequestering protein, has recently emerged as a multifunctional protein with several different activities. Genetic evidence in yeast and flies confirms that profilin is required for a normal actin cytoskeleton, while biochemical evidence suggests a role in regulating phosphoinositide signalling. New studies suggest that profilin may interact with other ligands, and even its role in regulating actin polymerization is now being re-evaluated.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura
Authors: Machesky, L. M., and Pollard, T. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Trends in Cell Biology
Publisher:Elsevier
ISSN:0962-8924
ISSN (Online):1879-3088

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