The Arp2/3 complex: a multifunctional actin organizer

Machesky, L. M. and Gould, K. L. (1999) The Arp2/3 complex: a multifunctional actin organizer. Current Opinion in Cell Biology, 11(1), pp. 117-121. (doi: 10.1016/S0955-0674(99)80014-3) (PMID:10047519)

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The actin-related proteins (Arps) constitute a recently characterized family of proteins, many of which function as members of multiprotein complexes. The discovery that two family members, Arp2 and Arp3, act as multifunctional organizers of actin filaments in all eukaryotes has generated much excitement. Over the past two years, newly discovered properties of the Arp2/3 complex have suggested a central role in the control of actin polymerization. First, it promotes actin assembly on the surface of the motile intracellular pathogen Listeria monocytogenes. Second, it can nucleate and cross-link actin filaments in vitro. Third, it localizes with dynamic actin-rich spots of mammalian cells suggesting a role in protrusion; it is found in cortical actin patches in the budding and fission yeasts where it may control patch movement and cortical actin function. Clearly, the complex has a central role in actin cytoskeletal function and will be the subject of much research in the coming years.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura
Authors: Machesky, L. M., and Gould, K. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Current Opinion in Cell Biology
ISSN (Online):1879-0410
Published Online:07 June 1999

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