Actin on trafficking: could actin guide directed receptor transport?

Zech, T., Calaminus, S. and Machesky, L. (2012) Actin on trafficking: could actin guide directed receptor transport? Cell Adhesion and Migration, 6(6), pp. 476-481. (doi: 10.4161/cam.21373) (PMID:23076144) (PMCID:PMC3547890)

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Here, we present emerging ideas surrounding the interplay between the actin cytoskeleton and receptor transport and activation. The bulk of actin dynamics in cells is thought to contribute to architecture and mobility. Actin also contributes to trafficking, acting as a molecular scaffold, providing force to deform membranes, facilitating vesicle abscission or propelling a vesicle through the cytoplasm1,2 and recent studies highlight important connections between the directed trafficking of receptors and the impact on cell migration and actin dynamics. Additionally, a number of newly described actin nucleation promoting factors, such as the vesicle associated protein WASH, reveal unexpected roles of actin in membrane traffic and suggest that the cell dedicates a significant proportion of its regulation of actin dynamics to controlling trafficking.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Calaminus, Dr Simon and Zech, Mr Tobias and Machesky, Professor Laura
Authors: Zech, T., Calaminus, S., and Machesky, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cell Adhesion and Migration
Publisher:Taylor & Francis
ISSN (Online):1933-6926
Published Online:17 October 2012
Copyright Holders:Copyright Copyright © 2012 Landes Bioscience
First Published:First published in Cell Adhesion and Migration 6(6):476-481
Publisher Policy:Reproduced under a Creative Commons Licence

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