Casolino, R. et al. (2021) Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine. Annals of Oncology, 32(2), pp. 183-196. (doi: 10.1016/j.annonc.2020.11.013) (PMID:33248227) (PMCID:PMC7840891)
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Abstract
This review summarises the recent evidence on preoperative therapeutic strategies in pancreatic cancer and discusses the rationale for an imminent need for a personalized therapeutic approach in non-metastatic disease. The molecular diversity of pancreatic cancer and its influence on prognosis and treatment response, combined with the failure of “all-comer” treatments to significantly impact on patient outcomes, requires a paradigm shift towards a genomic-driven approach. This is particularly important in the preoperative, potentially curable setting, where a personalized treatment allocation has the substantial potential to reduce pancreatic cancer mortality.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Chang, Professor David and Dreyer, Dr Stephan and Biankin, Professor Andrew and Froeling, Dr Fieke and Braconi, Professor Chiara and Casolino, Dr Raffaella |
| Authors: | Casolino, R., Braconi, C., Malleo, G., Paiella, S., Bassi, C., Milella, M., Dreyer, S.B., Froeling, F.E.M., Chang, D.K., Biankin, A.V., and Golan, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Annals of Oncology |
| Publisher: | Elsevier |
| ISSN: | 0923-7534 |
| ISSN (Online): | 1569-8041 |
| Published Online: | 25 November 2020 |
| Copyright Holders: | Copyright © 2020 The Authors |
| First Published: | First published in Annals of Oncology 32(2):183-196 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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