CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Lenk, L. et al. (2021) CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Communications Biology, 4, 73. (doi: 10.1038/s42003-020-01591-z) (PMID:33452446) (PMCID:PMC7810877)

Abstract

Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and –relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.

• Item Type: Articles
• Additional Information: Open Access funding enabled and organized by Projekt DEAL.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cousins, Dr Antony and Halsey, Professor Chris
• Authors: Lenk, L., Carlet, M., Vogiatzi, F., Spory, L., Winterberg, D., Cousins, A., Vossen-Gajcy, M., Ibruli, O., Vokuhl, C., Cario, G., El Ayoubi, O., Kramer, L., Ritgen, M., Brüggemann, M., Häsler, R., Schrappe, M., Fuhrmann, S., Halsey, C., Jeremias, I., Hobeika, E., Jumaa, H., Alsadeq, A., and Schewe, D. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Communications Biology
• Publisher: Nature Research
• ISSN: 2399-3642
• ISSN (Online): 2399-3642
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Communications Biology 4:73
• Publisher Policy: Reproduced under a Creative Commons License