CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Lenk, L. et al. (2021) CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Communications Biology, 4, 73. (doi: 10.1038/s42003-020-01591-z) (PMID:33452446) (PMCID:PMC7810877)

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Abstract

Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and –relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.

Item Type:Articles
Additional Information:Open Access funding enabled and organized by Projekt DEAL.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cousins, Dr Antony and Halsey, Professor Chris
Authors: Lenk, L., Carlet, M., Vogiatzi, F., Spory, L., Winterberg, D., Cousins, A., Vossen-Gajcy, M., Ibruli, O., Vokuhl, C., Cario, G., El Ayoubi, O., Kramer, L., Ritgen, M., Brüggemann, M., Häsler, R., Schrappe, M., Fuhrmann, S., Halsey, C., Jeremias, I., Hobeika, E., Jumaa, H., Alsadeq, A., and Schewe, D. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Communications Biology
Publisher:Nature Research
ISSN:2399-3642
ISSN (Online):2399-3642
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Communications Biology 4:73
Publisher Policy:Reproduced under a Creative Commons License

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