Portable molecularly imprinted polymer-based platform for detection of histamine in aqueous solutions

Venkatesh, S., Yeung, C.-C., Li, T., Lau, S. C., Sun, Q.-J., Li, L.-Y., Li, J. H., Lam, M. H.W. and Roy, V. A. L. (2021) Portable molecularly imprinted polymer-based platform for detection of histamine in aqueous solutions. Journal of Hazardous Materials, 310, 124609. (doi: 10.1016/j.jhazmat.2020.124609) (PMID:33257120)

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Abstract

Histamine, which is a naturally occurring chemical in seafood, is known to cause undesirable inflammatory response when consumed in large amounts. Histamine is produced in unsafe amounts in colored seafood when improperly stored for just a few hours. Food and health regulatory bodies across the world have guidelines limiting the amount of histamine in fresh as well as processed seafood. Conventional histamine detection is performed in testing labs, which is a slow process and results in bottlenecks in the seafood supply-chain system. A system to rapidly detect the seafood histamine levels on site is very desirable for seafood suppliers. Herein, we describe an impedance-based histamine detection sensor built on a flexible substrate that can detect histamine in the range of 100–500 ppm. Moreover, our sensor discriminates histamine in the presence of DL-histidine and other biogenic amines, with the selectivity provided by molecular imprinting technology. As a proof of concept, a smartphone controlled, portable semi-quantitative histamine sensing device was fabricated that gave out reliable testing results for histamine in different test solutions as well as for real seafood. We believe this technology can be extended towards determination of other food contaminants in aqueous solutions.

Item Type:Articles
Additional Information:This work was supported by the Research Grant Council of Hong Kong Special Administrative Region Project No. T42-103/16N.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vellaisamy, Professor Roy
Creator Roles:
Roy, V. A.L.Supervision
Authors: Venkatesh, S., Yeung, C.-C., Li, T., Lau, S. C., Sun, Q.-J., Li, L.-Y., Li, J. H., Lam, M. H.W., and Roy, V. A. L.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Journal of Hazardous Materials
Publisher:Elsevier
ISSN:0304-3894
ISSN (Online):1873-3336
Published Online:21 November 2020
Copyright Holders:Copyright © 2020 Crown Copyright
First Published:First published in Journal of Hazardous Materials 410: 124609
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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