Wang, Y. et al. (2021) Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications. Theranostics, 11(1), pp. 164-180. (doi: 10.7150/thno.47841)
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Abstract
Atherosclerosis (AS), the underlying cause of most cardiovascular events, is one of the most common causes of human morbidity and mortality worldwide due to the lack of an efficient strategy for targeted therapy. In this work, we aimed to develop an ideal biomimetic nanoparticle for targeted AS therapy. Methods: Based on macrophage “homing” into atherosclerotic lesions and cell membrane coating nanotechnology, biomimetic nanoparticles (MM/RAPNPs) were fabricated with a macrophage membrane (MM) coating on the surface of rapamycin-loaded poly (lactic-co-glycolic acid) copolymer (PLGA) nanoparticles (RAPNPs). Subsequently, the physical properties of the MM/RAPNPs were characterized. The biocompatibility and biological functions of MM/RAPNPs were determined in vitro. Finally, in AS mouse models, the targeting characteristics, therapeutic efficacy and safety of the MM/RAPNPs were examined. Results: The advanced MM/RAPNPs demonstrated good biocompatibility. Due to the MM coating, the nanoparticles effectively inhibited the phagocytosis by macrophages and targeted activated endothelial cells in vitro. In addition, MM-coated nanoparticles effectively targeted and accumulated in atherosclerotic lesions in vivo. After a 4-week treatment program, MM/RAPNPs were shown to significantly delay the progression of AS. Furthermore, MM/RAPNPs displayed favorable safety performance after long-term administration. Conclusion: These results demonstrate that MM/RAPNPs could efficiently and safely inhibit the progression of AS. These biomimetic nanoparticles may be potential drug delivery systems for safe and effective anti-AS applications.
Item Type: | Articles |
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Additional Information: | Financial support from the National Natural Science Foundation of China (31971301, 31971242, 12032007), the China Postdoctoral Science Foundation (2020M673143), the Natural Science Foundation of Chongqing (cstc2020jcyj-bsh0025, cstc2019jcyj-zdxm X0028, cstc2017jcyjAX0186) and Fundamental Research Funds for Central Universities (2020CDJQY- A061, 2019CDYGZD008, 2018CDHB1B08) as well as the National “111 Project” Base (B0625) are gratefully acknowledged. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Mcginty, Dr Sean |
Authors: | Wang, Y., Zhang, K., Li, T., Maruf, A., Qin, X., Luo, L., Zhong, Y., Qiu, J., McGinty, S., Pontrelli, G., Liao, X., Wu, W., and Wang, G. |
College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
Journal Name: | Theranostics |
Publisher: | Ivyspring International Publisher |
ISSN: | 1838-7640 |
ISSN (Online): | 1838-7640 |
Published Online: | 09 October 2020 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Theranostics 11(1): 164-180 |
Publisher Policy: | Reproduced under a Creative Commons License |
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