Dynamic proteome in enigmatic preeclampsia: an account of molecular mechanisms and biomarker discovery

Mary, S. , Patil, G. V., Kulkarni, A. V., Kulkarni, M. J., Joshi, S. R., Mehendale, S. S. and Giri, A. P. (2012) Dynamic proteome in enigmatic preeclampsia: an account of molecular mechanisms and biomarker discovery. Proteomics Clinical Applications, 6(1-2), pp. 79-90. (doi: 10.1002/prca.201100089) (PMID:22447695)

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Abstract

The coevolution of genomics and proteomics has led to advancements in the field of diagnosis and molecular mechanisms of disease. Proteomics is now stepping into the field of obstetrics, where early diagnosis of pregnancy complication such as preeclampsia (PE) is imperative. PE is a multifactorial disease characterized by hypertension with proteinuria, which is a leading cause of maternal and neonatal morbidity and mortality occurring in 5‐7% of pregnancies worldwide. This review discusses the probable molecular mechanisms that lead to PE and summarizes the proteomics research carried out in understanding the pathogenicity of PE, and for identifying the candidate biomarker for diagnosis of the disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Samji, Dr Sheon
Authors: Mary, S., Patil, G. V., Kulkarni, A. V., Kulkarni, M. J., Joshi, S. R., Mehendale, S. S., and Giri, A. P.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Proteomics Clinical Applications
Publisher:Wiley
ISSN:1862-8346
ISSN (Online):1862-8354
Published Online:24 March 2012

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