Kulkarni, M. J., Korwar, A. M., Mary, S. , Bhonsle, H. S. and Giri, A. P. (2013) Glycated proteome: from reaction to intervention. Proteomics Clinical Applications, 7(1-2), pp. 155-170. (doi: 10.1002/prca.201200101) (PMID:23184864)
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Abstract
Glycation, a nonenzymatic reaction between reducing sugars and proteins, is a proteome wide phenomenon, predominantly observed in diabetes due to hyperglycemia. Glycated proteome of plasma, kidney, lens, and brain are implicated in the pathogenesis of various diseases, including diabetic complications, neurodegenerative diseases, cancer, and aging. This review discusses the strategies to characterize protein glycation, its functional implications in different diseases, and intervention strategies to protect the deleterious effects of protein glycation.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Samji, Dr Sheon |
| Authors: | Kulkarni, M. J., Korwar, A. M., Mary, S., Bhonsle, H. S., and Giri, A. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Proteomics Clinical Applications |
| Publisher: | Wiley |
| ISSN: | 1862-8346 |
| ISSN (Online): | 1862-8354 |
| Published Online: | 26 November 2012 |
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