Advanced glycation end products (AGEs) in diabetic complications

Bhat, S., Mary, S. , Giri, A. P. and Kulkarni, M. J. (2017) Advanced glycation end products (AGEs) in diabetic complications. In: Kartha, C.C., Ramachandran, S. and Pillai, R. M. (eds.) Mechanisms of Vascular Defects in Diabetes Mellitus. Series: Advances in biochemistry in health and disease (17). Springer: Cham, pp. 423-449. ISBN 9783319603230 (doi: 10.1007/978-3-319-60324-7_19)

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Hyperglycemic condition in diabetes accelerates formation of advanced glycation end products (AGEs) that are formed as a result of series of reaction between reducing sugars and proteins. Accumulation of AGEs has been implicated in development of insulin resistance as well as in the pathogenesis of diabetic complications. The principal mechanism by which AGEs render harmful effects is through interaction with cell bound receptors. Certain receptors like AGE-R1 are involved in degradation of AGEs, while certain other receptors like receptor for AGE (RAGE) bring about counter effects exacerbating the situation. Accumulation of diverse AGEs, synergistically down regulate AGE-R1 while up regulate RAGE causing vicious cycle leading to enhanced formation and further accumulation of AGEs. In this article we discuss the formation of heterogeneous AGEs, importance of detection and quantification of AGEs, biological degradation of AGEs via different receptors, AGE-RAGE and its role in proinflammatory signaling, AGE mediated diabetic vascular complications such as nephropathy, retinopathy, neuropathy, cardiovascular and cerebrovascular diseases and finally the biological inhibition of AGEs is discussed along with chemical inhibitors for AGEs and natural products in AGE inhibition as a measure for the prevention of diabetic complications.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Samji, Dr Sheon
Authors: Bhat, S., Mary, S., Giri, A. P., and Kulkarni, M. J.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Published Online:03 August 2017

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