Cardiovascular proteomics

Mary, S. , Currie, G. , Schutte, A. E. and Delles, C. (2020) Cardiovascular proteomics. In: Faintuch, J. and Faintuch, S. (eds.) Precision Medicine for Investigators, Practitioners and Providers. Academic Press: London ; San Diego, CA, pp. 263-270. ISBN 9780128191781 (doi: 10.1016/b978-0-12-819178-1.00025-3)

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Cardiovascular diseases are the major cause of morbidity and mortality worldwide. They develop over long periods of time, and are typically caused by multiple factors, and interaction with the environment. Proteomics allows simultaneous quantification of multiple protein markers in a biosample, and therefore offers opportunities for precise individual definition of risk profiles, prediction, and diagnosis of disease. Proteomic biomarkers can also be used for monitoring of disease progression, and response to therapy. The large amount of information that can be obtained from comprehensive studies of the proteome naturally feeds into concepts of precision medicine, and has the potential not only to target preventative and therapeutic strategies to individual patients, but also to identify new therapeutic principles. In this chapter we will provide an overview of proteomic techniques, and how they can be applied in cardiovascular medicine.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Samji, Dr Sheon and Delles, Professor Christian and Currie, Dr Gemma
Authors: Mary, S., Currie, G., Schutte, A. E., and Delles, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Publisher:Academic Press
Published Online:22 November 2019

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