Distemper, extinction and vaccination of the Amur tiger

Gilbert, M. et al. (2020) Distemper, extinction and vaccination of the Amur tiger. Proceedings of the National Academy of Sciences of the United States of America, 117(50), pp. 31954-31962. (doi: 10.1073/pnas.2000153117) (PMID:33229566) (PMCID:PMC7749280)

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Abstract

Canine distemper virus (CDV) has recently emerged as an extinction threat for the endangered Amur tiger (Panthera tigris altaica). CDV is vaccine-preventable, and control strategies could require vaccination of domestic dogs and/or wildlife populations. However, vaccination of endangered wildlife remains controversial, which has led to a focus on interventions in domestic dogs, often assumed to be the source of infection. Effective decision making requires an understanding of the true reservoir dynamics, which poses substantial challenges in remote areas with diverse host communities. We carried out serological, demographic, and phylogenetic studies of dog and wildlife populations in the Russian Far East to show that a number of wildlife species are more important than dogs, both in maintaining CDV and as sources of infection for tigers. Critically, therefore, because CDV circulates among multiple wildlife sources, dog vaccination alone would not be effective at protecting tigers. We show, however, that low-coverage vaccination of tigers themselves is feasible and would produce substantive reductions in extinction risks. Vaccination of endangered wildlife provides a valuable component of conservation strategies for endangered species.

Item Type:Articles
Additional Information:This work was funded by the Morris Animal Foundation (D13Z0-041), the Zoo Boise Conservation Fund, Biotechnology and Biological Sciences Research Council (BB/F016786/1, BB/R004250/1), and the Wildlife Conservation Society.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Willett, Professor Brian and Hinds, Dr Chris and Reeve, Professor Richard and Davis, Dr Chris and Wilkie, Dr Gavin and Gilbert, Martin and Vattipally, Dr Sreenu and Hernandez Castro, Mr Luis and McDonald, Mr Mike and Thomson, Professor Emma and Cleaveland, Professor Sarah and Logan, Miss Nicola and Matthews, Professor Louise and Adamson, Dr Walt
Authors: Gilbert, M., Sulikhan, N., Uphyrkina, O., Goncharuk, M., Kerley, L., Hernandez Castro, E., Reeve, R., Seimon, T., McAloose, D., Seryodkin, I. V., Naidenko, S. V., Davis, C. A., Wilkie, G. S., Vattipally, S. B., Adamson, W. E., Hinds, C., Thomson, E. C., Willett, B. J., Hosie, M. J., Logan, N., McDonald, M., Ossiboff, R. J., Shevtsova, E. I., Belyakin, S., Yurlova, A. A., Osofsky, S. A., Miquelle, D. G., Matthews, L., and Cleaveland, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Proceedings of the National Academy of Sciences of the United States of America
Publisher:National Academy of Sciences
ISSN:0027-8424
ISSN (Online):1091-6490
Published Online:23 November 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Proceedings of the National Academy of Sciences 117(50):31954-31962
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
301313Atypical bovine morbillivirus infections in the Serengeti ecosystemBrian WillettBiotechnology and Biological Sciences Research Council (BBSRC)BB/R004250/1III - Centre for Virus Research
160803BBSRC Doctoral Training Grant 2009-15Massimo PalmariniBiotechnology and Biological Sciences Research Council (BBSRC)BB/F016786/1III - Centre for Virus Research