Gilbert, M. et al. (2020) Distemper, extinction and vaccination of the Amur tiger. Proceedings of the National Academy of Sciences of the United States of America, 117(50), pp. 31954-31962. (doi: 10.1073/pnas.2000153117) (PMID:33229566) (PMCID:PMC7749280)
![[img]](https://eprints.gla.ac.uk/style/images/fileicons/text.png) |
Text
226078.pdf - Published Version Available under License Creative Commons Attribution. 1MB |
Abstract
Canine distemper virus (CDV) has recently emerged as an extinction threat for the endangered Amur tiger (Panthera tigris altaica). CDV is vaccine-preventable, and control strategies could require vaccination of domestic dogs and/or wildlife populations. However, vaccination of endangered wildlife remains controversial, which has led to a focus on interventions in domestic dogs, often assumed to be the source of infection. Effective decision making requires an understanding of the true reservoir dynamics, which poses substantial challenges in remote areas with diverse host communities. We carried out serological, demographic, and phylogenetic studies of dog and wildlife populations in the Russian Far East to show that a number of wildlife species are more important than dogs, both in maintaining CDV and as sources of infection for tigers. Critically, therefore, because CDV circulates among multiple wildlife sources, dog vaccination alone would not be effective at protecting tigers. We show, however, that low-coverage vaccination of tigers themselves is feasible and would produce substantive reductions in extinction risks. Vaccination of endangered wildlife provides a valuable component of conservation strategies for endangered species.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was funded by the Morris Animal Foundation (D13Z0-041), the Zoo Boise Conservation Fund, Biotechnology and Biological Sciences Research Council (BB/F016786/1, BB/R004250/1), and the Wildlife Conservation Society. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hosie, Professor Margaret and Wilkie, Dr Gavin and Gilbert, Martin and Logan, Miss Nicola and Willett, Professor Brian and Vattipally, Dr Sreenu and Matthews, Professor Louise and Hernandez Castro, Mr Luis and Hinds, Dr Chris and McDonald, Mr Mike and Thomson, Professor Emma and Adamson, Dr Walt and Cleaveland, Professor Sarah and Reeve, Professor Richard and Davis, Dr Chris |
| Authors: | Gilbert, M., Sulikhan, N., Uphyrkina, O., Goncharuk, M., Kerley, L., Hernandez Castro, E., Reeve, R., Seimon, T., McAloose, D., Seryodkin, I. V., Naidenko, S. V., Davis, C. A., Wilkie, G. S., Vattipally, S. B., Adamson, W. E., Hinds, C., Thomson, E. C., Willett, B. J., Hosie, M. J., Logan, N., McDonald, M., Ossiboff, R. J., Shevtsova, E. I., Belyakin, S., Yurlova, A. A., Osofsky, S. A., Miquelle, D. G., Matthews, L., and Cleaveland, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Proceedings of the National Academy of Sciences of the United States of America |
| Publisher: | National Academy of Sciences |
| ISSN: | 0027-8424 |
| ISSN (Online): | 1091-6490 |
| Published Online: | 23 November 2020 |
| Copyright Holders: | Copyright © 2020 The Authors |
| First Published: | First published in Proceedings of the National Academy of Sciences 117(50):31954-31962 |
| Publisher Policy: | Reproduced under a Creative Commons license |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information