Arribas, S. M., González, J. M., Briones, A. M., Somoza, B., Daly, C. J. , Vila, E., González, M. C. and McGrath, J. C. (2007) Confocal myography for the study of hypertensive vascular remodelling. Clinical Hemorheology and Microcirculation, 37(1-2), pp. 205-210.
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Publisher's URL: https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch1016
Abstract
Hypertension is associated with vascular structural alterations known as “vascular remodelling”, which initially are adaptive but in the long run, lead to vascular damage and loss of function. Despite decades of study, there is still modest information on the 3-dimensional (3D) arrangement of vascular cells and extracellular matrix (ECM) and how they change under pathological situations. To address this problem we developed a technique which combines fluorescence confocal microscopy, pressure myography and image analysis, “confocal myography”, which permits the study of intact resistance-sized vessels at cellular level and at physiological pressure. With the aid of this method, we have identified, in arteries from hypertensive rats, abnormal orientation of endothelial, smooth muscle cells (SMC) and elastic fibres; elongation and denudation of endothelial cells, and adventitial hypercellularity. Confocal myography offers a new approach to the study of vascular remodelling in intact small arteries from a 3D point of view.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McGrath, Professor John and Daly, Professor Craig |
Authors: | Arribas, S. M., González, J. M., Briones, A. M., Somoza, B., Daly, C. J., Vila, E., González, M. C., and McGrath, J. C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences |
Journal Name: | Clinical Hemorheology and Microcirculation |
Publisher: | IOS Press |
ISSN: | 1386-0291 |
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