Morris, J. et al. (2020) Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank. Genes, 11(11), 1326. (doi: 10.3390/genes11111326) (PMID:33182605) (PMCID:PMC7697406)
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Abstract
Individuals with severe mental illness have an increased risk of cardiometabolic diseases compared to the general population. Shared risk factors and medication effects explain part of this excess risk; however, there is growing evidence to suggest that shared biology (including genetic variation) is likely to contribute to comorbidity between mental and physical illness. Contactins are a family of genes involved in development of the nervous system and implicated, though genome-wide association studies, in a wide range of psychological, psychiatric and cardiometabolic conditions. Contactins are plausible candidates for shared pathology between mental and physical health. We used data from UK Biobank to systematically assess how genetic variation in contactin genes was associated with a wide range of psychological, psychiatric and cardiometabolic conditions. We also investigated whether associations for cardiometabolic and psychological traits represented the same or distinct signals and how the genetic variation might influence the measured traits. We identified: A novel genetic association between variation in CNTN1 and current smoking; two independent signals in CNTN4 for BMI; and demonstrated that associations between CNTN5 and neuroticism were distinct from those between CNTN5 and blood pressure/HbA1c. There was no evidence that the contactin genes contributed to shared aetiology between physical and mental illness.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Morris, Dr. Rer. N Julia and Smith, Professor Daniel and Cullen, Dr Breda and Graham, Dr Nicholas and Ferguson, Ms Amy and Lyall, Dr Laura and Bailey, Dr Mark and Ward, Dr Joey and Johnston, Ms Keira and Strawbridge, Dr Rona and Lyall, Dr Donald |
Creator Roles: | Morris, J.Formal analysis, Writing – original draft Bailey, M. E.S.Writing – review and editing Cullen, B.Data curation, Writing – review and editing Ferguson, A.Writing – review and editing Graham, N.Data curation, Writing – review and editing Johnston, K. J.A.Writing – review and editing Lyall, D. M.Writing – review and editing Lyall, L. M.Writing – review and editing Ward, J.Data curation, Writing – review and editing Smith, D. J.Project administration, Writing – review and editing Strawbridge, R. J.Conceptualization, Writing – original draft |
Authors: | Morris, J., Leung, S. S. Y., Bailey, M. E.S., Cullen, B., Ferguson, A., Graham, N., Johnston, K. J.A., Lyall, D. M., Lyall, L. M., Ward, J., Smith, D. J., and Strawbridge, R. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Genes |
Publisher: | MDPI |
ISSN: | 2073-4425 |
ISSN (Online): | 2073-4425 |
Copyright Holders: | Copyright © 2020 by the authors |
First Published: | First published in Genes 11(11):1326 |
Publisher Policy: | Reproduced under a Creative Commons license |
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