Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank

Morris, J. et al. (2020) Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank. Genes, 11(11), 1326. (doi: 10.3390/genes11111326) (PMID:33182605) (PMCID:PMC7697406)

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Abstract

Individuals with severe mental illness have an increased risk of cardiometabolic diseases compared to the general population. Shared risk factors and medication effects explain part of this excess risk; however, there is growing evidence to suggest that shared biology (including genetic variation) is likely to contribute to comorbidity between mental and physical illness. Contactins are a family of genes involved in development of the nervous system and implicated, though genome-wide association studies, in a wide range of psychological, psychiatric and cardiometabolic conditions. Contactins are plausible candidates for shared pathology between mental and physical health. We used data from UK Biobank to systematically assess how genetic variation in contactin genes was associated with a wide range of psychological, psychiatric and cardiometabolic conditions. We also investigated whether associations for cardiometabolic and psychological traits represented the same or distinct signals and how the genetic variation might influence the measured traits. We identified: A novel genetic association between variation in CNTN1 and current smoking; two independent signals in CNTN4 for BMI; and demonstrated that associations between CNTN5 and neuroticism were distinct from those between CNTN5 and blood pressure/HbA1c. There was no evidence that the contactin genes contributed to shared aetiology between physical and mental illness.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ferguson, Ms Amy and Morris, Dr. Rer. N Julia and Smith, Professor Daniel and Lyall, Dr Laura and Bailey, Dr Mark and Ward, Dr Joey and Johnston, Ms Keira and Cullen, Dr Breda and Strawbridge, Dr Rona and Lyall, Dr Donald and Graham, Dr Nicholas
Creator Roles:
Morris, J.Formal analysis, Writing – original draft
Bailey, M. E.S.Writing – review and editing
Cullen, B.Data curation, Writing – review and editing
Ferguson, A.Writing – review and editing
Graham, N.Data curation, Writing – review and editing
Johnston, K. J.A.Writing – review and editing
Lyall, D. M.Writing – review and editing
Lyall, L. M.Writing – review and editing
Ward, J.Data curation, Writing – review and editing
Smith, D. J.Project administration, Writing – review and editing
Strawbridge, R. J.Conceptualization, Writing – original draft
Authors: Morris, J., Leung, S. S. Y., Bailey, M. E.S., Cullen, B., Ferguson, A., Graham, N., Johnston, K. J.A., Lyall, D. M., Lyall, L. M., Ward, J., Smith, D. J., and Strawbridge, R. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Genes
Publisher:MDPI
ISSN:2073-4425
ISSN (Online):2073-4425
Copyright Holders:Copyright © 2020 by the authors
First Published:First published in Genes 11(11):1326
Publisher Policy:Reproduced under a Creative Commons license

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