Emerging immunotherapies for metastasis

Edwards, S. C., Hoevenaar, W. H.M. and Coffelt, S. B. (2021) Emerging immunotherapies for metastasis. British Journal of Cancer, 124, pp. 37-48. (doi: 10.1038/s41416-020-01160-5) (PMID:33262520)

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Abstract

Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types of immunotherapy is the immune checkpoint inhibitors, such as anti-CTLA-4 and anti-PD-1, that keep anti-tumour T cells active. However, not every patient with metastatic disease benefits from this class of drugs and patients often develop resistance to these therapies over time. Tremendous research effort is now underway to uncover new immunotherapeutic targets that can be used in patients who are refractory to anti-CTLA-4 or anti-PD-1 treatment. Here, we discuss results from experimental model systems demonstrating that modulating the immune response can negatively affect metastasis formation. We focus on molecules that boost anti-tumour immune cells and opportunities to block immunosuppression, as well as cell-based therapies with enhanced tumour recognition properties for solid tumours. We also present a list of challenges in treating metastatic disease with immunotherapy that must be considered in order to move laboratory observations into clinical practice and maximise patient benefit.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Edwards, Dr Sarah and Coffelt, Dr Seth and Hoevenaar, Ms Wilma
Authors: Edwards, S. C., Hoevenaar, W. H.M., and Coffelt, S. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:British Journal of Cancer
Publisher:Nature Research
ISSN:0007-0920
ISSN (Online):1532-1827
Published Online:02 December 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in British Journal of Cancer 124:37–48
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174115CRUK Centre RenewalOwen SansomCancer Research UK (CRUK)C7932/A25142CS - Beatson Institute for Cancer Research
303457Regulation of IL-17-producing T cells in breast cancer metastasisSeth CoffeltBreast Cancer Now (BRCANNOW)2018JulPR1101CS - Beatson Institute for Cancer Research
301837Insights into the behaviour of anti-metastatic T cellsSeth CoffeltTenovus Scotland (TENOVUS)S17-17CS - Beatson Institute for Cancer Research