Bi-directional communication: Conversations between fibroblasts and immune cells in systemic sclerosis

Worrell, J. C. and O'Reilly, S. (2020) Bi-directional communication: Conversations between fibroblasts and immune cells in systemic sclerosis. Journal of Autoimmunity, 113, 102526. (doi: 10.1016/j.jaut.2020.102526) (PMID:32713676)

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Abstract

Systemic Sclerosis (SSc) is an autoimmune idiopathic connective tissue disease, characterized by aberrant fibro-proliferative and inflammatory responses, causing fibrosis of multiple organs. In recent years the interactions between innate and adaptive immune cells with resident fibroblasts have been uncovered. Cross-talk between immune and stromal cells mediates activation of stromal cells to myofibroblasts; key cells in the pathophysiology of fibrosis. These cells and their cytokines appear to mediate their effects in both a paracrine and autocrine fashion. This review examines the role of innate and adaptive immune cells in SSc, focusing on recent advances that have illuminated our understanding of ongoing bi-directional communication between immune and stromal cells. Finally, we appraise current and future therapies and how these may be useful in a disease that currently has no specific disease modifying treatment.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Worrell, Dr Julie
Authors: Worrell, J. C., and O'Reilly, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Autoimmunity
Publisher:Elsevier
ISSN:0896-8411
ISSN (Online):1095-9157
Published Online:24 July 2020
Copyright Holders:Copyright © 2020 Elsevier
First Published:First published in Journal of Autoimmunity 113:102526
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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