An optimal oscillatory phase for pattern reactivation during memory retrieval

Kerrén, C., Linde-Domingo, J., Hanslmayr, S. and Wimber, M. (2018) An optimal oscillatory phase for pattern reactivation during memory retrieval. Current Biology, 28(21), 3383-3392.e6. (doi: 10.1016/j.cub.2018.08.065) (PMID:30344116)

[img] Text
223733.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

1MB

Abstract

Computational models and in vivo studies in rodents suggest that the hippocampal system oscillates between states that are optimal for encoding and states that are optimal for retrieval. Here, we show that in humans, neural signatures of memory reactivation are modulated by the phase of a theta oscillation. Electroencephalography (EEG) was recorded while participants were cued to recall previously learned word-object associations, and time-resolved pattern classifiers were trained to detect neural reactivation of the target objects. Classifier fidelity rhythmically fluctuated at 7 or 8 Hz and was modulated by theta phase across the entire recall period. The phase of optimal classification was shifted approximately 180° between encoding and retrieval. Inspired by animal work, we then computed “classifier-locked averages” to analyze how ongoing theta oscillations behaved around the time points at which the classifier indicated memory retrieval. We found strong theta (7 or 8 Hz) phase consistency approximately 300 ms before the time points of maximal neural memory reactivation. Our findings provide important evidence that the neural signatures of memory retrieval fluctuate and are time locked to the phase of an ongoing theta oscillation.

Item Type:Articles
Additional Information:his work was supported by a fellowship from Stiftelsen Olle Engkvist Byggmästare awarded to M.W., a PhD scholarship from the BBSRC Midlands Integrative Biosciences Training Partnership (MIBTP) awarded to J.L.-D. and M.W., and C.K. and a starting grant from the European Research Council awarded to M.W. (ERC-2016-STG-715714).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hanslmayr, Professor Simon and Wimber, Dr Maria
Creator Roles:
Hanslmayr, S.Methodology, Writing – review and editing
Authors: Kerrén, C., Linde-Domingo, J., Hanslmayr, S., and Wimber, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Current Biology
Publisher:Elsevier (Cell Press)
ISSN:0960-9822
ISSN (Online):1879-0445
Published Online:18 October 2018
Copyright Holders:Copyright © 2018 Elsevier Ltd.
First Published:First published in Current Biology 28(21): 3383-3392.e6
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record