Application of a 2D molybdenum telluride in SERS-detection of biorelevant molecules

Fraser, J. P., Postnikov, P., Miliutina, E., Kolska, Z., Valiev, R., Švorčík, V., Lyutakov, O., Ganin, A. Y. and Guselnikova, O. (2020) Application of a 2D molybdenum telluride in SERS-detection of biorelevant molecules. ACS Applied Materials and Interfaces, 12(42), pp. 47774-47783. (doi: 10.1021/acsami.0c11231) (PMID:32985181)

Abstract

Two-dimensional (2D) transition-metal dichalcogenides have become promising candidates for surface-enhanced Raman spectroscopy (SERS), but currently very few examples of detection of relevant molecules are available. Herein, we show the detection of the lipophilic disease marker β-sitosterol on few-layered MoTe2 films. The chemical vapor deposition (CVD)-grown films are capable of nanomolar detection, exceeding the performance of alternative noble-metal surfaces. We confirm that the enhancement occurs through the chemical enhancement (CE) mechanism via formation of a surface–analyte complex, which leads to an enhancement factor of ≈104, as confirmed by Fourier transform infrared (FTIR), UV–vis, and cyclic voltammetry (CV) analyses and density functional theory (DFT) calculations. Low values of signal deviation over a seven-layered MoTe2 film confirms the homogeneity and reproducibility of the results in comparison to noble-metal substrate analogues. Furthermore, β-sitosterol detection within cell culture media, a minimal loss of signal over 50 days, and the opportunity for sensor regeneration suggest that MoTe2 can become a promising new SERS platform for biosensing.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ganin, Dr Alexey and Fraser, Mr James
• Authors: Fraser, J. P., Postnikov, P., Miliutina, E., Kolska, Z., Valiev, R., Švorčík, V., Lyutakov, O., Ganin, A. Y., and Guselnikova, O.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: ACS Applied Materials and Interfaces
• Publisher: American Chemical Society
• ISSN: 1944-8244
• ISSN (Online): 1944-8252
• Published Online: 28 September 2020
• Copyright Holders: Copyright © 2020 American Chemical Society
• First Published: First published in ACS Applied Materials and Interfaces 12(42): 47774-47783
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
173359		Modular assembly of high temperature superconductors from dimensionally reduced iron-based chalcogenide blocks	Alexey Ganin	Engineering and Physical Sciences Research Council (EPSRC)	EP/P001653/1	Chemistry
172865		EPSRC DTP 16/17 and 17/18	Tania Galabova	Engineering and Physical Sciences Research Council (EPSRC)	EP/N509668/1	Research and Innovation Services
302151		Development of basal-plane active layered transition metal dichalcogenides for electrocatalytic hydrogen evolution reactions	Alexey Ganin	The Carnegie Trust for the Universities of Scotland (CARNEGTR)	RIG007428	Chemistry