Application of a 2D molybdenum telluride in SERS-detection of biorelevant molecules

Fraser, J. P., Postnikov, P., Miliutina, E., Kolska, Z., Valiev, R., Švorčík, V., Lyutakov, O., Ganin, A. Y. and Guselnikova, O. (2020) Application of a 2D molybdenum telluride in SERS-detection of biorelevant molecules. ACS Applied Materials and Interfaces, 12(42), pp. 47774-47783. (doi: 10.1021/acsami.0c11231) (PMID:32985181)

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Abstract

Two-dimensional (2D) transition-metal dichalcogenides have become promising candidates for surface-enhanced Raman spectroscopy (SERS), but currently very few examples of detection of relevant molecules are available. Herein, we show the detection of the lipophilic disease marker β-sitosterol on few-layered MoTe2 films. The chemical vapor deposition (CVD)-grown films are capable of nanomolar detection, exceeding the performance of alternative noble-metal surfaces. We confirm that the enhancement occurs through the chemical enhancement (CE) mechanism via formation of a surface–analyte complex, which leads to an enhancement factor of ≈104, as confirmed by Fourier transform infrared (FTIR), UV–vis, and cyclic voltammetry (CV) analyses and density functional theory (DFT) calculations. Low values of signal deviation over a seven-layered MoTe2 film confirms the homogeneity and reproducibility of the results in comparison to noble-metal substrate analogues. Furthermore, β-sitosterol detection within cell culture media, a minimal loss of signal over 50 days, and the opportunity for sensor regeneration suggest that MoTe2 can become a promising new SERS platform for biosensing.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ganin, Dr Alexey and Fraser, Dr James
Authors: Fraser, J. P., Postnikov, P., Miliutina, E., Kolska, Z., Valiev, R., Švorčík, V., Lyutakov, O., Ganin, A. Y., and Guselnikova, O.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:ACS Applied Materials and Interfaces
Publisher:American Chemical Society
ISSN:1944-8244
ISSN (Online):1944-8252
Published Online:28 September 2020
Copyright Holders:Copyright © 2020 American Chemical Society
First Published:First published in ACS Applied Materials and Interfaces 12(42): 47774-47783
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173359Modular assembly of high temperature superconductors from dimensionally reduced iron-based chalcogenide blocksAlexey GaninEngineering and Physical Sciences Research Council (EPSRC)EP/P001653/1Chemistry
172865EPSRC DTP 16/17 and 17/18Tania GalabovaEngineering and Physical Sciences Research Council (EPSRC)EP/N509668/1Research and Innovation Services
302151Development of basal-plane active layered transition metal dichalcogenides for electrocatalytic hydrogen evolution reactionsAlexey GaninThe Carnegie Trust for the Universities of Scotland (CARNEGTR)RIG007428Chemistry