Molecular epidemiology of Giardia infections in the genomic era

Capewell, P. , Krumrie, S. , Katzer, F., Alexander, C. L. and Weir, W. (2021) Molecular epidemiology of Giardia infections in the genomic era. Trends in Parasitology, 37(2), pp. 142-153. (doi: 10.1016/j.pt.2020.09.013) (PMID:33067130)

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Abstract

Giardia duodenalis is a major gastrointestinal parasite of humans and animals across the globe. It is also of interest from an evolutionary perspective as it possesses many features that are unique among the eukaryotes, including its distinctive binucleate cell structure. While genomic analysis of a small number of isolates has provided valuable insights, efforts to understand the epidemiology of the disease and the population biology of the parasite have been limited by the molecular tools currently available. We review these tools and assess the impact of affordable and rapid genome sequencing systems increasingly being deployed in diagnostic settings. While these technologies have direct implications for public and veterinary health, they will also improve our understanding of the unique biology of this fascinating parasite.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Weir, Professor Willie and Krumrie, Sarah and Alexander, Miss Claire and Capewell, Dr Paul
Authors: Capewell, P., Krumrie, S., Katzer, F., Alexander, C. L., and Weir, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Trends in Parasitology
Publisher:Elsevier (Cell Press)
ISSN:1471-4922
ISSN (Online):1471-5007
Published Online:13 October 2020
Copyright Holders:Copyright © 2020 Elsevier Ltd.
First Published:First published in Trends in Parasitology 37(2): 142-153
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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