Depression and anxiety in an Early Rheumatoid Arthritis inception cohort. Associations with demographic, socioeconomic and disease features

Fragkoulis, G., Cavanagh, J. , Tindell, A., Derakhshan, M., Paterson, C., Porter, D., McInnes, I. B. and Siebert, S. (2020) Depression and anxiety in an Early Rheumatoid Arthritis inception cohort. Associations with demographic, socioeconomic and disease features. RMD Open, 6, e001376. (doi: 10.1136/rmdopen-2020-001376) (PMID:33127857)

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Abstract

Objective: Depression and anxiety are not uncommon in Rheumatoid arthritis (RA). It is increasingly recognised that they are associated with high disease activity and worse disease outcomes. We aimed to examine the frequency of depression and anxiety in an early RA inception cohort and to explore associations with disease-related measures. Methods: The Scottish Early Rheumatoid Arthritis inception cohort recruited newly diagnosed RA patients followed-up 6-monthly. Anxiety and depression were assessed using the hospital anxiety and depression scale. Associations with demographic characteristics and disease-related measures were examined at baseline, 6 months and 12 months. Results: 848 RA patients were included. The prevalence of anxiety and depression at baseline was 19.0% and 12.2%, respectively. Depression and anxiety scores correlated with DAS28 at all time-points (all p<0.0001). In multivariable linear regression, anxiety score at baseline was associated with younger age and Health Assessment Questionnaire (HAQ) score. Anxiety scores at 6 months and 12 months were associated with low body mass index (BMI), baseline anxiety score and current patient global score and HAQ. Depression score at baseline was associated with younger age, being single and HAQ, while depression scores at 6 months and 12 months were associated with male gender (only at 6 months), baseline anxiety and depression scores and current patient global score, HAQ and C-reactive protein (CRP) levels. Conclusion: Depression and anxiety are associated with disease activity, worse functional status and other variables in early RA. There is a close relationship between CRP and depression but not anxiety.

Item Type:Articles
Additional Information:The SERA cohort was supported by joint funding from the Chief Scientist’s Office (award ref ETM-40) and Pfizer.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Cavanagh, Professor Jonathan and Porter, Dr Duncan and Fragkoulis, Dr Georgios and Tindell, Dr Alistair and Derakhshan, Dr Mohammad and Siebert, Professor Stefan and Paterson, Miss Caron
Authors: Fragkoulis, G., Cavanagh, J., Tindell, A., Derakhshan, M., Paterson, C., Porter, D., McInnes, I. B., and Siebert, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:RMD Open
Publisher:MDPI
ISSN:2056-5933
ISSN (Online):2056-5933
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in RMD Open 6:e001376
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
167249Scottish Early Rheumatoid Arthritis (SERA) bio-bank from an inception cohort of patients with newly diagnosed rheumatoid arthritisIan FordChief Scientist Office (CSO)ETM/40/CZB/4/783HW - Robertson Centre