Does insulin-like growth factor moderate the association between height and risk of cancer at 24 sites?

Parra Soto, S. L., Ho, F. K., Pell, J. P. and Celis-Morales, C. (2020) Does insulin-like growth factor moderate the association between height and risk of cancer at 24 sites? British Journal of Cancer, 123, pp. 1697-1704. (doi: 10.1038/s41416-020-01059-1) (PMID:32921791)

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Abstract

Background: Whether the association of height with cancers differs by insulin-like growth factors has not been fully elucidated. Therefore, this study aimed to investigate the sex-specific associations between height and 24 site-specific cancers and to assess whether the association differed by IGF-1. Methods: In total, 414,923 participants from the UK Biobank prospective cohort study were included. The association of height (per 5-cm increment) with incidence and mortality from 24 cancer sites was investigated by using Cox proportional hazard models. Results: The median follow-up was 6.0 years. In men, height was positively associated with incidence risk of all-cause cancer and at five sites (lung, lymphatic, leukaemia, non-Hodgkin lymphoma and melanoma). In women, it was associated with breast, melanoma, lymphatic, non-Hodgkin lymphoma and all-cause cancer. The association was stronger in women than men for all-cause cancer incidence. The strength of the association did not differ by IGF-1 concentration. Conclusions: Adult height was associated with risk of several cancer sites. However, some of these associations were sex-specific. There was no strong evidence to support IGF-1 moderating the association between height and cancer.

Item Type:Articles
Additional Information:Funding: SPS was funded by the Chilean Government PhD scholarship program.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ho, Dr Frederick and Parra Soto, Solange Liliana and Celis, Dr Carlos and Pell, Professor Jill
Authors: Parra Soto, S. L., Ho, F. K., Pell, J. P., and Celis-Morales, C.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:British Journal of Cancer
Publisher:Springer Nature
ISSN:0007-0920
ISSN (Online):1532-1827
Published Online:14 September 2020
Copyright Holders:Copyright © 2020 Springer Nature
First Published:First published in British Journal of Cancer 123:1697-1704
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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