Bacteriocins targeting Gram-negative phytopathogenic bacteria: plantibiotics of the future

Rooney, W. M. , Chai, R., Milner, J. L. and Walker, D. (2020) Bacteriocins targeting Gram-negative phytopathogenic bacteria: plantibiotics of the future. Frontiers in Microbiology, 11, 575981. (doi: 10.3389/fmicb.2020.575981) (PMCID:PMC7530242)

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Abstract

Gram-negative phytopathogenic bacteria are a significant threat to food crops. These microbial invaders are responsible for a plethora of plant diseases and can be responsible for devastating losses in crops such as tomatoes, peppers, potatoes, olives, and rice. Current disease management strategies to mitigate yield losses involve the application of chemicals which are often harmful to both human health and the environment. Bacteriocins are small proteinaceous antibiotics produced by bacteria to kill closely related bacteria and thereby establish dominance within a niche. They potentially represent a safer alternative to chemicals when used in the field. Bacteriocins typically show a high degree of selectivity toward their targets with no off-target effects. This review outlines the current state of research on bacteriocins active against Gram-negative phytopathogenic bacteria. Furthermore, we will examine the feasibility of weaponizing bacteriocins for use as a treatment for bacterial plant diseases.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Walker, Professor Daniel and Rooney, Dr Will and Milner, Dr Joel and Chai, Dr Ray
Authors: Rooney, W. M., Chai, R., Milner, J. L., and Walker, D.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Microbiology
Publisher:Frontiers Media
ISSN:1664-302X
ISSN (Online):1664-302X
Copyright Holders:Copyright © 2020 Rooney, Chai, Milner and Walker
First Published:First published in Frontiers in Microbiology 11:575981
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
307270Exploiting bacteriocins for plant protection against pathogenic bacteriaJoel MilnerBiotechnology and Biological Sciences Research Council (BBSRC)BB/T004207/1III - Bacteriology
190773A novel mechanism of protein uptake in Gram-negative bacteriaDaniel WalkerBiotechnology and Biological Sciences Research Council (BBSRC)BB/L02022X/1III - Bacteriology