Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis

Suchacki, K. J. et al. (2020) Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis. Nature Communications, 11, 3097. (doi: 10.1038/s41467-020-16878-2) (PMID:32555194) (PMCID:PMC7303125)

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Abstract

Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass, yet unlike white or brown adipose tissues (WAT or BAT) its metabolic functions remain unclear. Herein, we address this critical gap in knowledge. Our transcriptomic analyses revealed that BMAT is distinct from WAT and BAT, with altered glucose metabolism and decreased insulin responsiveness. We therefore tested these functions in mice and humans using positron emission tomography-computed tomography (PET/CT) with 18F-fluorodeoxyglucose. This revealed that BMAT resists insulin- and cold-stimulated glucose uptake, while further in vivo studies showed that, compared to WAT, BMAT resists insulin-stimulated Akt phosphorylation. Thus, BMAT is functionally distinct from WAT and BAT. However, in humans basal glucose uptake in BMAT is greater than in axial bones or subcutaneous WAT and can be greater than that in skeletal muscle, underscoring the potential of BMAT to influence systemic glucose homeostasis. These PET/CT studies characterise BMAT function in vivo, establish new methods for BMAT analysis, and identify BMAT as a distinct, major adipose tissue subtype.

Item Type:Articles
Additional Information:This work was supported by grants from the Medical Research Council (MR/M021394/1 to W.P.C.; MR/K010271/1 to R.H.S.), the National Institutes of Health (R01 DK62876 and R24 DK092759 to O.A.M.; K99-DE024178 to E.L.S.; and P30 DK089503 to the Michigan Nutrition Obesity Research Center), the Wellcome Trust-University of Edinburgh Institutional Strategic Support Fund (to W.P.C. and K.J.S.), and the British Heart Foundation (4-year BHF PhD Studentship to R.J.S., B.J.T., M.C.S. and B.M.N; BHF CoRE Bioinformatics Grant to W.P.C.; BHF CoRE grant to A.J.D.). W.P.C. is further supported by a Chancellor’s Fellowship from the University of Edinburgh. A.A.S.T was funded by the British Heart Foundation (RG/16/10/32375). E.J.R.v.B is supported by SINAPSE (the Scottish Imaging Network). We are grateful to the British Heart Foundation for providing funding towards establishment of the Edinburgh Preclinical PET/CT laboratory (RE/13/3/30183), and to NHS Research Scotland (NRS) for financial support of the Edinburgh Clinical Research Facility. R.H.S and M.C.W. are supported by The Chief Scientist Office of the Scottish Government (SCAF/17/02 to R.H.S.; PCL/17/04 to M.C.W.). J.P.M.A is supported by BHF Clinical Research Training Fellowship no. FS/17/51/33096.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sinton, Dr Matthew
Authors: Suchacki, K. J., Tavares, A. A. S., Mattiucci, D., Scheller, E. L., Papanastasiou, G., Gray, C., Sinton, M. C., Ramage, L. E., McDougald, W. A., Lovdel, A., Sulston, R. J., Thomas, B. J., Nicholson, B. M., Drake, A. J., Alcaide-Corral, C. J., Said, D., Poloni, A., Cinti, S., Macpherson, G. J., Dweck, M. R., Andrews, J. P. M., Williams, M. C., Wallace, R. J., van Beek, E. J. R., MacDougald, O. A., Morton, N. M., Stimson, R. H., and Cawthorn, W. P.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Nature Communications
Publisher:Nature Research
ISSN:2041-1723
ISSN (Online):2041-1723
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Nature Communications 11: 3097
Publisher Policy:Reproduced under a Creative Commons License

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