Assessing the effect of insecticide-treated cattle on tsetse abundance and trypanosome transmission at the wildlife-livestock interface in Serengeti, Tanzania

Lord, J. S. et al. (2020) Assessing the effect of insecticide-treated cattle on tsetse abundance and trypanosome transmission at the wildlife-livestock interface in Serengeti, Tanzania. PLoS Neglected Tropical Diseases, 14(8), e0008288. (doi: 10.1371/journal.pntd.0008288) (PMID:32841229) (PMCID:PMC7473525)

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Abstract

In the absence of national control programmes against Rhodesian human African trypanosomiasis, farmer-led treatment of cattle with pyrethroid-based insecticides may be an effective strategy for foci at the edges of wildlife areas, but there is limited evidence to support this. We combined data on insecticide use by farmers, tsetse abundance and trypanosome prevalence, with mathematical models, to quantify the likely impact of insecticide-treated cattle. Sixteen percent of farmers reported treating cattle with a pyrethroid, and chemical analysis indicated 18% of individual cattle had been treated, in the previous week. Treatment of cattle was estimated to increase daily mortality of tsetse by 5–14%. Trypanosome prevalence in tsetse, predominantly from wildlife areas, was 1.25% for T. brucei s.l. and 0.03% for T. b. rhodesiense. For 750 cattle sampled from 48 herds, 2.3% were PCR positive for T. brucei s.l. and none for T. b. rhodesiense. Using mathematical models, we estimated there was 8–29% increase in mortality of tsetse in farming areas and this increase can explain the relatively low prevalence of T. brucei s.l. in cattle. Farmer-led treatment of cattle with pyrethroids is likely, in part, to be limiting the spill-over of human-infective trypanosomes from wildlife areas.

Item Type:Articles
Additional Information:ST, HA, LM received funding from the Zoonosis and Emerging and Livestock Systems (ZELS) programme, Grant/Award Number: BB/L019035/1. JH received funding from the UNICEF/UNDP/ World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Grant/Award Number: 221948, ICONZ; Biotechnology and Biological Sciences Research Council; Department for International Development; The Economic and Social Science Research Council; The Natural Environment Research Council and the Defence, Science and Technology Laboratory; Canadian International Development Research Centre (IDRC); European Union’s Seventh Framework Program, Grant/Award Number: FP7/2007-2013; and ICONZ (Integrated Control of Neglected Zoonoses). LM, EP, FA received funding from the Biotechnology and Biological Sciences Research Council, Grant/ Award Number BBS/E/D/20002173.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Auty, Harriet
Creator Roles:
Auty, H. K.Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review and editing
Authors: Lord, J. S., Lea, R. S., Allan, F. K., Byamungu, M., Hall, D. R., Lingley, J., Mramba, F., Paxton, E., Vale, G. A., Hargrove, J. W., Morrison, L. J., Torr, S. J., and Auty, H. K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:PLoS Neglected Tropical Diseases
Publisher:Public Library of Science
ISSN:1935-2727
ISSN (Online):1935-2735
Published Online:25 August 2020
Copyright Holders:Copyright © 2020 Lord et al.
First Published:First published in PLoS Neglected Tropical Diseases 14(8): e0008288
Publisher Policy:Reproduced under a Creative Commons License
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