Omics derived biomarkers and novel drug targets for improved intervention in advanced prostate cancer

Frantzi, M., Hupe, M. C., Merseburger, A. S., Schanstra, J. P., Mischak, H. and Latosinska, A. (2020) Omics derived biomarkers and novel drug targets for improved intervention in advanced prostate cancer. Diagnostics, 10(9), 658. (doi: 10.3390/diagnostics10090658) (PMID:32878288)

Abstract

Prostate cancer (PCa) is one of the most frequently diagnosed malignancies, and the fifth leading cause of cancer related mortality in men. For advanced PCa, radical prostatectomy, radiotherapy, and/or long-term androgen deprivation therapy are the recommended treatment options. However, subsequent progression to metastatic disease after initial therapy results in low 5-year survival rates (29%). Omics technologies enable the acquisition of high-resolution large datasets that can provide insights into molecular mechanisms underlying PCa pathology. For the purpose of this article, a systematic literature search was conducted through the Web of Science Database to critically evaluate recent omics-driven studies that were performed towards: (a) Biomarker development and (b) characterization of novel molecular-based therapeutic targets. The results indicate that multiple omics-based biomarkers with prognostic and predictive value have been validated in the context of PCa, with several of those being also available for commercial use. At the same time, omics-driven potential drug targets have been investigated in pre-clinical settings and even in clinical trials, holding the promise for improved clinical management of advanced PCa, as part of personalized medicine pipelines.

• Item Type: Articles
• Additional Information: This research was funded by the BioGuidePCa Project (E! 11023, Eurostars), supported by the European Commission and the Federal Ministry of Education and Research in Germany (BMBF).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mischak, Professor Harald and Frantzi, Ms Maria

Creator Roles

Frantzi, M.: Conceptualization, Methodology, Formal analysis, Data curation, Writing – original draft, Writing – review and editing, Visualization
Mischak, H.: Conceptualization, Writing – review and editing, Funding acquisition

• Authors: Frantzi, M., Hupe, M. C., Merseburger, A. S., Schanstra, J. P., Mischak, H., and Latosinska, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Diagnostics
• Publisher: MDPI
• ISSN: 2075-4418
• ISSN (Online): 2075-4418
• Published Online: 31 August 2020
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Diagnostics 10(9): 658
• Publisher Policy: Reproduced under a Creative Commons License