PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study

Lyall, D. M. , Ward, J., Banach, M., Smith, G. D., Gill, J. G. , Pell, J. P. , Holmes, M. V. and Sattar, N. (2021) PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study. Archives of Medical Science, 17(1), pp. 241-244. (doi: 10.5114/aoms/127226)

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Abstract

Introduction: PCSK9 inhibitors lower low-density lipoprotein (LDL) cholesterol and are efficacious at reducing vascular disease, however questions remain about potential effects on cognitive function. Methods: We examined the association of genetic variants in PCSK9 with continuous measures of cognitive ability in UK Biobank. Six independent polymorphisms in PCSK9 were used in up to 337,348 individuals. Results: The PCSK9 allele score was associated with a lower risk of CHD, and weakly with worse log reaction time. Conclusions: We are unable to rule out meaningful associations of PCSK9 genetic variants with cognition, emphasising the potential need for continued pharmacovigilance for patients currently treated with PCSK9 inhibitors.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Pell, Professor Jill and Ward, Dr Joey and Gill, Professor Jason and Sattar, Professor Naveed and Lyall, Dr Donald
Authors: Lyall, D. M., Ward, J., Banach, M., Smith, G. D., Gill, J. G., Pell, J. P., Holmes, M. V., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Archives of Medical Science
Publisher:Termedia
ISSN:1734-1922
ISSN (Online):1896-9151
Copyright Holders:Copyright © 2020 Termedia & Banach
First Published:First published in Archives of Medical Science 17(1):241–244
Publisher Policy:Reproduced under a Creative Commons License

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