Read, write, adapt: challenges and opportunities during kinetoplastid genome replication

Damasceno, J. D., Marques, C. A., Black, J., Briggs, E. and McCulloch, R. (2021) Read, write, adapt: challenges and opportunities during kinetoplastid genome replication. Trends in Genetics, 37(1), pp. 21-34. (doi: 10.1016/j.tig.2020.09.002) (PMID:32993968)

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Abstract

The genomes of all organisms are read throughout their growth and development, generating new copies during cell division and encoding the cellular activities dictated by the genome’s content. However, genomes are not invariant information stores but are purposefully altered in minor and major ways, adapting cellular behaviour and driving evolution. Kinetoplastids are eukaryotic microbes that display a wide range of such read–write genome activities, in many cases affecting critical aspects of their biology, such as host adaptation. Here we discuss the range of read–write genome changes found in two well-studied kinetoplastid parasites, Trypanosoma brucei and Leishmania, focusing on recent work that suggests such adaptive genome variation is linked to novel strategies the parasites use to replicate their unconventional genomes.

Item Type:Articles
Additional Information:This publication was supported by the BBSRC [BB/N016165/1, BB/R017166/1], the MRC [MR/S019472/1], and has received funding from European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 750259 [Individual Fellowship, RECREPEMLE]. The Wellcome Centre for Integrative Parasitology is supported by core funding from the Wellcome Trust [104111].
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Black, Dr Jennifer and Damasceno, Dr Jeziel and Briggs, Miss Emma and McCulloch, Professor Richard
Authors: Damasceno, J. D., Marques, C. A., Black, J., Briggs, E., and McCulloch, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Genetics
Publisher:Elsevier (Cell Press)
ISSN:0168-9525
ISSN (Online):1362-4555
Published Online:28 September 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Trends in Genetics 37(1): 21-34
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173173How do common and diverged features of the replicative stress response shape the biology of TriTrypRichard McCullochBiotechnology and Biological Sciences Research Council (BBSRC)BB/N016165/1III - Parasitology
301963Does genome replication in the protozoan parasite Leishmania rely on origin-indepenent initiation?Richard McCullochBiotechnology and Biological Sciences Research Council (BBSRC)BB/R017166/1III - Parasitology
303747Digital-Chemical-Robotics for Translation of Code to Molecules and Complex Chemical SystemsLeroy CroninEngineering and Physical Sciences Research Council (EPSRC)EP/S019472/1Chemistry
171824Characterization of Toxoplasma gondii interaction with the human host cell and Host-Parasite co-evolution: Toxoplasma gondii as a case studyMusa HassanWellcome Trust (WELLCOTR)104111/B/14/ZIII - Parasitology