Highly sensitive detection of estradiol by a SERS sensor based on TiO2 covered with gold nanoparticles

Brognara, A., Mohamad Ali Nasri, I. F., Bricchi, B. R., Li Bassi, A., Gauchotte-Lindsay, C. , Ghidelli, M. and Lidgi-Guigui, N. (2020) Highly sensitive detection of estradiol by a SERS sensor based on TiO2 covered with gold nanoparticles. Beilstein Journal of Nanotechnology, 11, pp. 1026-1035. (doi: 10.3762/bjnano.11.87) (PMID:32733777) (PMCID:PMC7372251)

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Abstract

We propose the use of gold nanoparticles grown on the surface of nanoporous TiO2 films as surface-enhanced Raman scattering (SERS) sensors for the detection of 17β-estradiol. Gold deposition on top of a TiO2 surface leads to the formation of nanoparticles the plasmonic properties of which fulfil the requirements of a SERS sensor. The morphological and optical properties of the surface were investigated. Specifically, we demonstrate that the TiO2 background pressure during pulsed laser deposition and the annealing conditions offer control over the formation of Au nanoparticles with different sizes, shapes and distributions, yielding a versatile sensor. We have exploited the surface for the detection of 17β-estradiol, an emerging contaminant in environmental waters. We have found a limit of detection of 1 nM with a sensitivity allowing for a dynamic range of five orders of magnitude (up to 100 µM).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gauchotte-Lindsay, Dr Caroline
Authors: Brognara, A., Mohamad Ali Nasri, I. F., Bricchi, B. R., Li Bassi, A., Gauchotte-Lindsay, C., Ghidelli, M., and Lidgi-Guigui, N.
College/School:College of Science and Engineering > School of Engineering > Infrastructure and Environment
Journal Name:Beilstein Journal of Nanotechnology
Publisher:Beilstein-Institut
ISSN:2190-4286
Copyright Holders:Copyright © 2020 Brognara et al.
First Published:First published in Beilstein Journal of Nanotechnology 11:1026-1035
Publisher Policy:Reproduced under a Creative Commons licence

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