Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling

O'Toole, D., Zaeri, A. A. I., Nicklin, S. A. , French, A. T., Loughrey, C. M. and Martin, T. P. (2020) Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular Signalling, 76, 109770. (doi: 10.1016/j.cellsig.2020.109770) (PMID:32891693)

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Abstract

Adverse cardiac remodelling clinically manifests as deleterious changes to heart architecture (size, mass and geometry) and function. These changes, which include alterations to ventricular wall thickness, chamber dilation and poor contractility, are important because they progressively drive patients with cardiac disease towards heart failure and are associated with poor prognosis. Cysteine cathepsins contribute to key signalling pathways involved in adverse cardiac remodelling including synthesis and degradation of the cardiac extracellular matrix (ECM), cardiomyocyte hypertrophy, impaired cardiomyocyte contractility and apoptosis. In this review, we highlight the role of cathepsins in these signalling pathways as well as their translational potential as therapeutic targets in cardiac disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Zaeri, Ali Abdullah I and French, Professor Anne and O'Toole, Mr Dylan and Loughrey, Professor Christopher and Martin, Dr Tamara and Nicklin, Professor Stuart
Authors: O'Toole, D., Zaeri, A. A. I., Nicklin, S. A., French, A. T., Loughrey, C. M., and Martin, T. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Cellular Signalling
Publisher:Elsevier
ISSN:0898-6568
ISSN (Online):1873-3913
Published Online:04 September 2020
Copyright Holders:Crown Copyright © 2020
First Published:First published in Cellular Signalling 76:109770
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
301985Investigating the Therapeutic Potential of Runx1 for Myocardial InfarctionChristopher LoughreyBritish Heart Foundation (BHF)PG/18/9/33548CAMS - Cardiovascular Science