Disposable and Flexible Sensor Patch for α-amylase Detection in Human Blood Serum

Bhattacharjee, M. , Escobedo, P. and Dahiya, R. (2020) Disposable and Flexible Sensor Patch for α-amylase Detection in Human Blood Serum. In: IEEE Sensors 2020, 25-28 Oct 2020, ISBN 9781728168029 (doi:10.1109/SENSORS47125.2020.9278674)

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Abstract

Disposable and flexible sensors are needed in biomedical and healthcare applications because of hygiene requirements. At the same time, they should provide an affordable solution for point-of-care (POC) testing and large-scale deployment. In this view, herein we report flexible polyimide-based disposable sensor patch for the detection of a-amylase in blood serum. The concentration of a-amylase in blood serum is a potential indicator of health issues such as pancreatitis and pancreatic cancer and an affordable solution to detect its concentration could benefit many. Here, the detection is based on thermal Marangoni circulation inside a microfluidic droplet of starch-FeSO 4 salt solution, which detects the a-amylase concentration upon addition of blood serum. It was observed that the temperature difference between the droplet substrate and ambient sets a thermal Marangoni and natural convections motion inside the droplet. The performance of the microdropletbased sensor was best at temperature difference (~18–20°C). The sensor is capable of detecting 20-110 units/liter concentration of α-amylase with ~80% change in the electrical resistance across the microdroplet (at ~40°C substrate temperature), and with a sensitivity of 0.88% (units/liter) -1 . The response of the sensor was also compared with pathological laboratory results and both were found to be in agreement. The presented sensor has the potential to be used as a POC device for detecting α-amylase in real-time.

Item Type:Conference Proceedings
Additional Information:This work was supported in part by Engineering and Physical Sciences Research Council (EPSRC) Engineering Fellowship for Growth neuPRINTSKIN (EP/R029644/1 and EP/M002527/1) and North West Centre for Advanced Manufacturing (NW CAM) project supported by the European Union’s INTERREG VA Programme (H2020- Intereg-IVA5055), managed by the Special EU Programmes Body (SEUPB) and IISERB institute grant, Government of India through Grant No. INST/EEC/2020005.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Escobedo, Dr Pablo and Bhattacharjee, Mr Mitradip and Dahiya, Professor Ravinder
Authors: Bhattacharjee, M., Escobedo, P., and Dahiya, R.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
ISSN:1930-0395
ISBN:9781728168029
Copyright Holders:Copyright © 2020 IEEE
First Published:First published in Proceedings of 2020 IEEE Sensors
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
301728Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/R029644/1ENG - Electronics & Nanoscale Engineering
170185Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/M002527/1ENG - Electronics & Nanoscale Engineering