ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis

Dowsett, L. , Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C. and Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9(9), 3026. (doi: 10.3390/jcm9093026) (PMID:32962225) (PMCID:PMC7563400)

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Abstract

Atherosclerosis is a chronic cardiovascular disease which increases risk of major cardiovascular events including myocardial infarction and stroke. Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) have long been recognised as a hallmark of cardiovascular disease and are associated with cardiovascular risk factors including hypertension, obesity and hypertriglyceridemia. In this review, we discuss the clinical literature that link ADMA concentrations to increased risk of the development of atherosclerosis. The formation of atherosclerotic lesions relies on the interplay between vascular dysfunction, leading to endothelial activation and the accumulation of inflammatory cells, particularly macrophages, within the vessel wall. Here, we review the mechanisms through which elevated ADMA contributes to endothelial dysfunction, activation and reactive oxygen species (ROS) production; how ADMA may affect vascular smooth muscle phenotype; and finally whether ADMA plays a regulatory role in the inflammatory processes occurring within the vessel wall.

Item Type:Articles
Additional Information:The Institute of Cardiovascular and Medical Sciences is a recipient of a British Heart Foundation Centre of Research Excellence Award (RE/13/5/30177). E.H. is a recipient of a British Heart Foundation 4 year studentship (FS/17/63/33485). S.A. is funded by Al-Jouf University, Saudi Arabia. N.A. is funded by the King Saud University, Saudi Arabia.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Leiper, Dr Fiona and Alshuwayer, Noha and Leiper, Professor James and Alanazi, Sarah and Dowsett, Dr Laura and Higgins, Erin
Creator Roles:
Dowsett, L.Conceptualization, Writing – original draft, Writing – review and editing, Visualization
Higgins, E.Writing – original draft, Writing – review and editing
Alanazi, S.Writing – original draft, Writing – review and editing
Alshuwayer, N.Writing – original draft, Writing – review and editing
Leiper, F.Writing – review and editing
Leiper, J.Conceptualization, Writing – review and editing, Supervision, Funding acquisition
Authors: Dowsett, L., Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C., and Leiper, J.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Clinical Medicine
Publisher:MDPI
ISSN:2077-0383
ISSN (Online):2077-0383
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Journal of Clinical Medicine 9(9):3026
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190814BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177Institute of Cardiovascular & Medical Sciences
302108BHF 4-Year PhD Studentship Award 2017Rhian TouyzBritish Heart Foundation (BHF)FS/17/63/33485CAMS - Cardiovascular Science