The temporal signature of memories: identification of a general mechanism for dynamic memory replay in humans

Jensen, O. , Michelmann, S. , Bowman, H. and Hanslmayr, S. (2016) The temporal signature of memories: identification of a general mechanism for dynamic memory replay in humans. PLoS Biology, 14(8), e1002528. (doi: 10.1371/journal.pbio.1002528) (PMID:27494601) (PMCID:PMC4975452)

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Abstract

Reinstatement of dynamic memories requires the replay of neural patterns that unfold over time in a similar manner as during perception. However, little is known about the mechanisms that guide such a temporally structured replay in humans, because previous studies used either unsuitable methods or paradigms to address this question. Here, we overcome these limitations by developing a new analysis method to detect the replay of temporal patterns in a paradigm that requires participants to mentally replay short sound or video clips. We show that memory reinstatement is accompanied by a decrease of low-frequency (8 Hz) power, which carries a temporal phase signature of the replayed stimulus. These replay effects were evident in the visual as well as in the auditory domain and were localized to sensory-specific regions. These results suggest low-frequency phase to be a domain-general mechanism that orchestrates dynamic memory replay in humans.

Item Type:Articles
Additional Information:Funding: European Research Council Consolidator Grant awarded to SH (Grant Agreement 647954). Emmy Noether Programme Grant from the Deutsche Forschungsgemeinschaft awarded to SH (HA 5622/1-1).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hanslmayr, Professor Simon
Authors: Jensen, O., Michelmann, S., Bowman, H., and Hanslmayr, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:PLoS Biology
Publisher:Public Library of Science
ISSN:1544-9173
ISSN (Online):1545-7885
Published Online:05 August 2016
Copyright Holders:Copyright © 2016 Michelmann et al.
First Published:First published in PLoS Biology 14(8): e1002528
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.5061/dryad.ch110

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