Human hippocampal dynamics during response conflict

Oehrn, C. R. , Baumann, C. , Fell, J. , Lee, H. , Kessler, H. , Habel, U. , Hanslmayr, S. and Axmacher, N. (2015) Human hippocampal dynamics during response conflict. Current Biology, 25(17), pp. 2307-2313. (doi: 10.1016/j.cub.2015.07.032) (PMID:26299515)

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Abstract

Besides its relevance for declarative memory functions [1, 2, 3, 4, 5], hippocampal activation has been observed during disambiguation of uncertainty and conflict [6, 7]. Uncertainty and conflict may arise on various levels. On the perceptual level, the hippocampus has been associated with signaling of contextual deviance [8, 9, 10] and disambiguation of similar items (i.e., pattern separation) [11, 12, 13]. Furthermore, conflicts can occur on the response level. Animal experiments showed a role of the hippocampus for inhibition of prevailing response tendencies and suppression of automatic stimulus-response mappings [14, 15, 16, 17], potentially related to increased theta oscillations (3–8 Hz) [18]. In humans, a recent fMRI study demonstrated hippocampal involvement in approach-avoidance conflicts [19]. However, the more general significance of hippocampal activity for dealing with response conflicts also on a cognitive level is still unknown. Here, we investigated the role of the hippocampus for response conflict in the Stroop task by combining intracranial electroencephalography (iEEG) recordings from the hippocampus of epilepsy patients with region of interest-based fMRI in healthy participants. Both methods revealed converging evidence that the hippocampus is recruited in a regionally specific manner during response conflict. Moreover, our iEEG data show that this activation depends on theta oscillations and is relevant for successful response conflict resolution.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hanslmayr, Professor Simon
Authors: Oehrn, C. R., Baumann, C., Fell, J., Lee, H., Kessler, H., Habel, U., Hanslmayr, S., and Axmacher, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Current Biology
Publisher:Elsevier (Cell Press)
ISSN:0960-9822
ISSN (Online):1879-0445
Published Online:20 August 2015

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