Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Di Credico, G. et al. (2020) Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration. British Journal of Cancer, 123(9), pp. 1456-1463. (doi: 10.1038/s41416-020-01031-z) (PMID:32830199)

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Abstract

Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Item Type:Articles
Additional Information:This work was supported by grants from the: National Institutes of Health (NIH) [no grant number provided for the INHANCE Pooled Data Project, grant numbers P01CA068384, K07CA104231 for the New York Multicenter study, grant numbers R01CA048996, R01DE012609 for the Seattle (1985-1995) study, grant number TW001500 for the Fogarty International Research Collaboration Award (FIRCA) supporting the Iowa study, grant number R01CA061188 for the North Carolina (1994–1997) study, grant numbers P01CA068384, K07CA104231, R01DE013158 for the Tampa study, grant numbers P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667 for the Los Angeles study, grant numbers R01CA078609, R01CA100679 for the Boston study, grant number R01CA051845 for the MSKCC study, grant number R01CA030022 for the Seattle-Leo study, grant number DE016631 for the Baltimore study, no grant number provided for the Puerto Rico study]; National Cancer Institute (NCI) at the National Institutes of Health (NIH) [grant number R03CA113157 for the INHANCE Pooled Data Project, no grant number provided for the Intramural Program supporting the Puerto Rico study, grant number R01CA90731-01 for the North Carolina (2002–2006) study]; National Institute of Dental and Craniofacial Research (NIDCR) at the National Institutes of Health (NIH) [grant number R03DE016611 for the INHANCE Pooled Data Project, grant numbers R01DE011979, R01DE013110 for the Iowa study, no grant number provided for the Intramural Program supporting the Puerto Rico study]; Italian Association for Research on Cancer (AIRC) [no grant number provided for the Milan (1984–1989) study, for the Aviano study, for the Italy Multicenter study, grant number 10068 for the Milan (2006–2009) study]; Italian League against Cancer [no grant number provided for the Aviano and Italy Multicenter studies]; Italian Ministry of Research [no grant number provided for the Italy Multicenter study]; Ministero della Salute Ricerca Corrente [no grant number provided for the Aviano study]; the Swiss Research against cancer/Oncosuisse [grant numbers KFS-700, OCS-1633 for the Switzerland study, grant number KFS1096-09-2000 for the France (1987–1992) study]; European Commission [grant number IC18-CT97-0222 (INCO-DC Program) for the Latin America study]; Veterans Affairs Merit Review Funds [no grant number provided for the Iowa study]; National Institute of Environmental Health Sciences (NIEHS) [grant number P30ES010126 for the North Carolina (1994–1997) study, National Cancer Institute (NCI) [grant number R01-CA90731for the North Carolina (2002–2006) study]; Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center [no grant number provided for the Los Angeles study]; Fondo para la Investigacion Cientifica y Tecnologica Argentina (FONCYT) [no grant number provided for the Latin America study]; Institut Hospital del Mar d’Investigacions Mediquès (IMIM) [no grant number provided for the Latin America study]; Fundação de Amparo à Pesquisa no Estado de São Paulo (FAPESP) [grant number 01/01768-2 for the Latin America study, grant numbers GENCAPO 04/12054-9, 10/51168-0 for the Sao Paulo study]; Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government [grant number FIS 97/0024, FIS 97/0662, BAE 01/5013 for the International Multicenter study]; International Union Against Cancer (UICC) [no grant number provided for the International Multicenter study]; Yamagiwa-Yoshida Memorial International Cancer Study Grant [no grant number provided for the International Multicenter study]; European Community (5th Framework Programme) [grant number QLK1-CT-2001-00182 for the Western Europe study]; Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan [grant number 17015052 for the Japan (2001–2005) study]; Third-Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan [grant number H20-002 for the Japan (2001–2005) study]; Italian Foundation for Cancer Research (FIRC) [no grant number provided for the Milan (2006–2009) study]; Italian Ministry of Education—PRIN 2009 Program [grant number X8YCBN for the Milan study (2006–2009) study]; Fribourg League against Cancer [grant number FOR381.88 for the France (1987–1992) study]; Swiss Cancer Research [grant number AKT 617 for the France (1987–1992) study]; Gustave-Roussy Institute [grant number 88D28 for the France (1987–1992) study]; French National Research Agency (ANR) [no grant number provided for the France Multicenter (2001–2007) study]; French National Cancer Institute (INCA) [no grant number provided for the France Multicenter (2001–2007) study]; French Agency for Food, Environmental and Occupational Health and Safety (ANSES) [no grant number provided for the France Multicenter (2001–2007) study]; French Institute for Public Health Surveillance (InVS) [no grant number provided for the France Multicenter (2001–2007) study]; Fondation pour la Recherche Médicale (FRM) [no grant number provided for the France Multicenter (2001–2007) study]; Fondation de France [no grant number provided for the France Multicenter (2001–2007) study]; Fondation ARC pour la Recherche sur le Cancer [no grant number provided for the France Multicenter (2001–2007) study]; French Ministry of Labour (Direction Générale du Travail) [no grant number provided for the France Multicenter (2001–2007) study]; French Ministry of Health (Direction Générale de la Santé) [no grant number provided for the France Multicenter (2001–2007) study]; V.E. was supported by Università degli Studi di Milano ‘Young Investigator Grant Program 2017’.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Conway, Professor David
Authors: Di Credico, G., Polesel, J., Dal Maso, L., Pauli, F., Torelli, N., Luce, D., Radoï, L., Matsuo, K., Serraino, D., Brennan, P., Holcatova, I., Ahrens, W., Lagiou, P., Canova, C., Richiardi, L., Healy, C. M., Kjaerheim, K., Conway, D. I., Macfarlane, G. J., Thomson, P., Agudo, A., Znaor, A., Franceschi, S., Herrero, R., Toporcov, T. N., Moyses, R. A., Muscat, J., Negri, E., Vilensky, M., Fernandez, L., Curado, M. P., Menezes, A., Daudt, A. W., Koifman, R., Wunsch-Filho, V., Olshan, A. F., Zevallos, J. P., Sturgis, E. M., Li, G., Levi, F., Zhang, Z.-F., Morgenstern, H., Smith, E., Lazarus, P., La Vecchia, C., Garavello, W., Chen, C., Schwartz, S. M., Zheng, T., Vaughan, T. L., Kelsey, K., McClean, M., Benhamou, S., Hayes, R. B., Purdue, M. P., Gillison, M., Schantz, S., Yu, G.-P., Chuang, S.-C., Boffetta, P., Hashibe, M., Yuan-Chin, A. L., and Edefonti, V.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:British Journal of Cancer
Publisher:Springer Nature
ISSN:0007-0920
ISSN (Online):1532-1827
Published Online:24 August 2020
Copyright Holders:Copyright © 2020 Springer Nature
First Published:First published in British Journal of Cancer 123(9):1456–1463
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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