Clinical and laboratory diagnosis of SARS-CoV-2, the virus causing COVID-19

da Silva, S. J. R., da Silva, C. T. A., Guarines, K. M., Mendes, R. P. G., Pardee, K., Kohl, A. and Pena, L. (2020) Clinical and laboratory diagnosis of SARS-CoV-2, the virus causing COVID-19. ACS Infectious Diseases, 6(9), pp. 2319-2336. (doi: 10.1021/acsinfecdis.0c00274) (PMID:32786280) (PMCID:PMC7441751)

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Abstract

In December 2019, a novel beta (β) coronavirus eventually named SARS-CoV-2 emerged in Wuhan, Hubei province, China causing an outbreak of severe and even fatal pneumonia in humans. The virus has spread very rapidly to many countries across the world, resulting in the World Health Organization (WHO) to declare a pandemic on March 11, 2020. Clinically, the diagnosis of this unprecedented illness, called coronavirus disease-2019 (COVID-19), becomes difficult because it shares many symptoms with other respiratory pathogens, including influenza and parainfluenza viruses. Therefore, laboratory diagnosis is crucial for clinical management of patients and the implementation of disease control strategies to contain SARS-CoV-2 at clinical and population level. Here, we summarize the main clinical and imaging findings of COVID-19 patients and discuss the advances, features, advantages, and limitations of different laboratory methods used for SARS-CoV-2 diagnosis.

Item Type:Articles
Keywords:Coronavirus, coronavirus disease 2019, COVID-19, diagnostics, imaging findings, laboratory, respiratory pathogens, SARS-CoV-2, pandemic.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kohl, Professor Alain
Authors: da Silva, S. J. R., da Silva, C. T. A., Guarines, K. M., Mendes, R. P. G., Pardee, K., Kohl, A., and Pena, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:ACS Infectious Diseases
Publisher:American Chemical Society
ISSN:2373-8227
ISSN (Online):2373-8227
Published Online:04 August 2020
Copyright Holders:Copyright © 2020 American Chemical Society
First Published:First published in ACS Infectious Diseases 6(9) 2319-2336
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656551Arbovirus interactions with arthropod hostsAlain KohlMedical Research Council (MRC)MC_UU_12014/8MVLS III - CENTRE FOR VIRUS RESEARCH