Clinical and laboratory diagnosis of SARS-CoV-2, the virus causing COVID-19

da Silva, S. J. R., da Silva, C. T. A., Guarines, K. M., Mendes, R. P. G., Pardee, K., Kohl, A. and Pena, L. (2020) Clinical and laboratory diagnosis of SARS-CoV-2, the virus causing COVID-19. ACS Infectious Diseases, 6(9), pp. 2319-2336. (doi: 10.1021/acsinfecdis.0c00274) (PMID:32786280) (PMCID:PMC7441751)

Abstract

In December 2019, a novel beta (β) coronavirus eventually named SARS-CoV-2 emerged in Wuhan, Hubei province, China causing an outbreak of severe and even fatal pneumonia in humans. The virus has spread very rapidly to many countries across the world, resulting in the World Health Organization (WHO) to declare a pandemic on March 11, 2020. Clinically, the diagnosis of this unprecedented illness, called coronavirus disease-2019 (COVID-19), becomes difficult because it shares many symptoms with other respiratory pathogens, including influenza and parainfluenza viruses. Therefore, laboratory diagnosis is crucial for clinical management of patients and the implementation of disease control strategies to contain SARS-CoV-2 at clinical and population level. Here, we summarize the main clinical and imaging findings of COVID-19 patients and discuss the advances, features, advantages, and limitations of different laboratory methods used for SARS-CoV-2 diagnosis.

• Item Type: Articles
• Keywords: Coronavirus, coronavirus disease 2019, COVID-19, diagnostics, imaging findings, laboratory, respiratory pathogens, SARS-CoV-2, pandemic.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kohl, Professor Alain
• Authors: da Silva, S. J. R., da Silva, C. T. A., Guarines, K. M., Mendes, R. P. G., Pardee, K., Kohl, A., and Pena, L.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: ACS Infectious Diseases
• Publisher: American Chemical Society
• ISSN: 2373-8227
• ISSN (Online): 2373-8227
• Published Online: 04 August 2020
• Copyright Holders: Copyright © 2020 American Chemical Society
• First Published: First published in ACS Infectious Diseases 6(9) 2319-2336
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
65655	1	Arbovirus interactions with arthropod hosts	Alain Kohl	Medical Research Council (MRC)	MC_UU_12014/8	MVLS III - CENTRE FOR VIRUS RESEARCH