Evanescent wave optical trapping and sensing on polymer optical fibers for ultra-trace detection of glucose

Azargoshasb, T., Navid, H. A., Parvizi, R. and Heidari, H. (2020) Evanescent wave optical trapping and sensing on polymer optical fibers for ultra-trace detection of glucose. ACS Omega, 5(35), pp. 22046-22056. (doi: 10.1021/acsomega.0c01908) (PMID:32923763) (PMCID:PMC7482082)

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Graphene sensitization of glucose-imprinted polymer (G-IP)-coated optical fiber has been introduced as a new biosensor for evanescent wave trapping on the polymer optical fiber to detect low-level glucose. The developed sensor operates based on the evanescent wave modulation principle. Full characterization via atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), Raman spectroscopy, high-resolution transmission electron microscopy (HRTEM), and N2 adsorption/desorption of as-prepared G-IP-coated optical fibers was experimentally tested. Accordingly, related operational parameters such as roughness and diameter were optimized. Incorporating graphene into the G-IP not only steadily promotes the electron transport between the fiber surface and as-proposed G-IP but also significantly enhances the sensitivity by acting as a carrier for immobilizing G-IP with specific imprinted cavities. The sensor demonstrates a fast response time (5 s) and high sensitivity, selectivity, and stability, which cause a wide linear range (10–100 nM) and a low limit of detection (LOD = 2.54 nM). Experimental results indicate that the developed sensor facilitates online monitoring and remote sensing of glucose in biological liquids and food samples.

Item Type:Articles
Additional Information:This work was supported by the Research Council of the University of Yasouj (Grant no. Gryu-89131107). We thank Alireza Nikzad (Yasouj University) for providing synthesis and Saeed Azad (École de Technologie Supérieure Montréal, Canada) optical setups and materials synthesis.
Glasgow Author(s) Enlighten ID:Heidari, Dr Hadi
Authors: Azargoshasb, T., Navid, H. A., Parvizi, R., and Heidari, H.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:ACS Omega
Publisher:American Chemical Society
ISSN (Online):2470-1343
Published Online:25 August 2020
Copyright Holders:Copyright © 2020 American Chemical Society
First Published:First published in ACS Omega 5(35): 22046-22056
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
304896EPSRC-IAA: Early Stage Commercialisation of a PET Imaging Agent for the Detection of Cardiovascular Disease and CancerAndrew SutherlandEngineering and Physical Sciences Research Council (EPSRC)EP/R511705/1Chemistry