Kennedy, E. D., Choy, K. C.C., Alston, R. P., Chen, S., Farhan-Alanie, M. M.H., Anderson, J., Ang, Y. L., Moore, D. E., MacKenzie, S. A. and Sykes, R. A. (2013) Cognitive outcome after on- and off-pump coronary artery bypass grafting surgery: a systematic review and meta-analysis. Journal of Cardiothoracic and Vascular Anesthesia, 27(2), pp. 253-265. (doi: 10.1053/j.jvca.2012.11.008) (PMID:23507014)
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Abstract
Objective: The aim of this study was to compare cognition following coronary artery bypass grafting (CABG) surgery with or without cardiopulmonary bypass (CPB) (on- or off-pump). Design: Systematic review and meta-analysis of randomized control trials comparing cognitive outcome in patients undergoing CABG surgery on- or off-pump as assessed by continuous measures from a battery of 7 psychometric tests. Setting: Multi-institutional centers performing CABG surgery. Participants: Patients with coronary artery disease requiring CABG surgery. Interventions: CABG surgery with or without CPB. Measurements and main results: A structured literature search identified 13 randomized control trials that included a total of 2,405 patients. Results from 7 psychometric tests were grouped into early (≤3 months) and late (6-12 months) postoperative periods. No significant differences were found between on- and off-pump groups in any of the 7 psychometric tests in either the early (p range 0.21-0.78) or late (p range 0.09-0.93) postoperative period. Conclusion: The results suggested that CPB may not be associated with cognitive decline that is associated with CABG surgery.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sykes, Dr Robert |
| Authors: | Kennedy, E. D., Choy, K. C.C., Alston, R. P., Chen, S., Farhan-Alanie, M. M.H., Anderson, J., Ang, Y. L., Moore, D. E., MacKenzie, S. A., and Sykes, R. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Cardiothoracic and Vascular Anesthesia |
| Publisher: | Elsevier |
| ISSN: | 1053-0770 |
| ISSN (Online): | 1532-8422 |
| Published Online: | 15 March 2013 |
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