The effect of postoperative complications on survival and recurrence after surgery for breast cancer: a systematic review and meta-analysis

Savioli, F., Edwards, J. , McMillan, D. , Stallard, S., Doughty, J. and Romics, L. (2020) The effect of postoperative complications on survival and recurrence after surgery for breast cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 155, 103075. (doi: 10.1016/j.critrevonc.2020.103075) (PMID:32987333)

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Abstract

Background: This systematic review investigated the impact of complications on long term outcomes for patients with primary invasive operable breast cancer. Methods: A systematic review was performed using appropriate keywords, and meta-analysis using a random effects model completed. Results: Ten retrospective cohort studies, including 37657 patients were included. Five studies identified a relationship between wound complications, infection and pyrexia and recurrence or recurrence-free survival. Risk of recurrence, 1-year and 5-year recurrence-free survival and overall survival were related to complications, particularly for patients with poor Nottingham Prognostic Index. Five studies failed to demonstrate a relationship between complications and prognosis. Complication was found to significantly affect 5-year recurrence-free survival (HR 1.48 95% CI 1.02-2.14, p = 0.04) but not recurrence (HR 2.39, 95%CI 0.94-6.07, p = 0.07), with a high degree of heterogeneity among analysed studies (I2 = 95%). Discussion: Further research is needed to quantify the effects of postoperative complication on prognosis following surgery for breast cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Romics, Mr Laszlo and Edwards, Professor Joanne and Savioli, Ms Francesca and Doughty, Miss Julie and McMillan, Professor Donald
Authors: Savioli, F., Edwards, J., McMillan, D., Stallard, S., Doughty, J., and Romics, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Critical Reviews in Oncology/Hematology
Publisher:Elsevier
ISSN:1040-8428
ISSN (Online):1879-0461
Published Online:18 August 2020
Copyright Holders:Copyright © 2020 Elsevier B.V.
First Published:First published in Critical Reviews in Oncology/Hematology 155: 103075
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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