Long-range phase synchronization of high-frequency oscillations in human cortex

Arnulfo, G. et al. (2020) Long-range phase synchronization of high-frequency oscillations in human cortex. Nature Communications, 11, 5363. (doi: 10.1038/s41467-020-18975-8) (PMID:33097714) (PMCID:PMC7584610)

Abstract

Inter-areal synchronization of neuronal oscillations at frequencies below ~100 Hz is a pervasive feature of neuronal activity and is thought to regulate communication in neuronal circuits. In contrast, faster activities and oscillations have been considered to be largely local-circuit-level phenomena without large-scale synchronization between brain regions. We show, using human intracerebral recordings, that 100–400 Hz high-frequency oscillations (HFOs) may be synchronized between widely distributed brain regions. HFO synchronization expresses individual frequency peaks and exhibits reliable connectivity patterns that show stable community structuring. HFO synchronization is also characterized by a laminar profile opposite to that of lower frequencies. Importantly, HFO synchronization is both transiently enhanced and suppressed in separate frequency bands during a response-inhibition task. These findings show that HFO synchronization constitutes a functionally significant form of neuronal spike-timing relationships in brain activity and thus a mesoscopic indication of neuronal communication per se.

• Item Type: Articles
• Additional Information: This study was supported by the Academy of Finland (J.M.P., project numbers: 253130, 256472, 281414, 296304, 266745; S.P., 266402, 266745, 303933, 325404), by the Juselius Foundation (J.M.P., S.P.), by the Helsinki University Research Funds (J.M.P., S.P.), and by the Finnish Cultural Foundation (G.A., 12938). The research leading to these results has received funding from the European Union Seventh Framework Program (FP7/2007-2013, J.M.P., S.P.) under grant agreement no. 604102 (Human Brain Project). G.A. was partially funded by Fondazione San Paolo (20670).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Palva, Professor Satu and Palva, Professor Matias
• Authors: Arnulfo, G., Wang, S.H., Myrov, V., Toselli, B., Hirvonen, J., Fato, M.M., Nobili, L., Cardinale, F., Rubino, A., Zhigalov, A., Palva, S., and Palva, J.M.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Nature Communications
• Publisher: Nature Research
• ISSN: 2041-1723
• ISSN (Online): 2041-1723
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Nature Communications 11: 5363
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
172779		Human Brain Project	Lars Muckli	European Commission (EC)	Muckli, Professor Lars	NP - Centre for Cognitive Neuroimaging (CCNi)