The impact of malaria parasites on dendritic cell–T cell interaction

Osii, R. S., Otto, T. D. , Garside, P. , Ndungu, F. and Brewer, J. M. (2020) The impact of malaria parasites on dendritic cell–T cell interaction. Frontiers in Immunology, 11, 1597. (doi: 10.3389/fimmu.2020.01597)

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Abstract

Malaria is caused by apicomplexan parasites of the genus Plasmodium. While infection continues to pose a risk for the majority of the global population, the burden of disease mainly resides in Sub-Saharan Africa. Although immunity develops against disease, this requires years of persistent exposure and is not associated with protection against infection. Repeat infections occur due to the parasite's ability to disrupt or evade the host immune responses. However, despite many years of study, the mechanisms of this disruption remain unclear. Previous studies have demonstrated a parasite-induced failure in dendritic cell (DCs) function affecting the generation of helper T cell responses. These T cells fail to help B cell responses, reducing the production of antibodies that are necessary to control malaria infection. This review focuses on our current understanding of the effect of Plasmodium parasite on DC function, DC-T cell interaction, and T cell activation. A better understanding of how parasites disrupt DC-T cell interactions will lead to new targets and approaches to reinstate adaptive immune responses and enhance parasite immunity.

Item Type:Articles
Additional Information:RO is a PhD student supported under FN’s MRC/DFID African Research Leadership Award (MR/P020321/1) and the DELTAS Africa Initiative (DEL-15-003). The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS)’s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa’s Development Planning and Coordinating Agency (NEPAD Agency) with funding from the Wellcome Trust (107769/Z/10/Z) and the UK government. This research received funding from the University of Glasgow, Scottish Funding Council, and the Global Challenges Research Fund.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Brewer, Professor James and Garside, Professor Paul and Ndungu, Dr Francis and Otto, Dr Thomas and Osii, Rowland
Authors: Osii, R. S., Otto, T. D., Garside, P., Ndungu, F., and Brewer, J. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Immunology
Publisher:Frontiers Media
ISSN:1664-3224
ISSN (Online):1664-3224
Copyright Holders:Copyright © 2020 Osii, Otto, Garside, Ndungu and Brewer.
First Published:First published in Frontiers in Immunology 11:1597
Publisher Policy:Reproduced under a Creative Commons license

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