Osii, R. S., Otto, T. D. , Garside, P. , Ndungu, F. and Brewer, J. M. (2020) The impact of malaria parasites on dendritic cell–T cell interaction. Frontiers in Immunology, 11, 1597. (doi: 10.3389/fimmu.2020.01597)
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Abstract
Malaria is caused by apicomplexan parasites of the genus Plasmodium. While infection continues to pose a risk for the majority of the global population, the burden of disease mainly resides in Sub-Saharan Africa. Although immunity develops against disease, this requires years of persistent exposure and is not associated with protection against infection. Repeat infections occur due to the parasite's ability to disrupt or evade the host immune responses. However, despite many years of study, the mechanisms of this disruption remain unclear. Previous studies have demonstrated a parasite-induced failure in dendritic cell (DCs) function affecting the generation of helper T cell responses. These T cells fail to help B cell responses, reducing the production of antibodies that are necessary to control malaria infection. This review focuses on our current understanding of the effect of Plasmodium parasite on DC function, DC-T cell interaction, and T cell activation. A better understanding of how parasites disrupt DC-T cell interactions will lead to new targets and approaches to reinstate adaptive immune responses and enhance parasite immunity.
Item Type: | Articles |
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Additional Information: | RO is a PhD student supported under FN’s MRC/DFID African Research Leadership Award (MR/P020321/1) and the DELTAS Africa Initiative (DEL-15-003). The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS)’s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa’s Development Planning and Coordinating Agency (NEPAD Agency) with funding from the Wellcome Trust (107769/Z/10/Z) and the UK government. This research received funding from the University of Glasgow, Scottish Funding Council, and the Global Challenges Research Fund. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ndungu, Dr Francis and Otto, Professor Thomas and Brewer, Professor James and Garside, Professor Paul and Osii, Rowland |
Authors: | Osii, R. S., Otto, T. D., Garside, P., Ndungu, F., and Brewer, J. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
Journal Name: | Frontiers in Immunology |
Publisher: | Frontiers Media |
ISSN: | 1664-3224 |
ISSN (Online): | 1664-3224 |
Copyright Holders: | Copyright © 2020 Osii, Otto, Garside, Ndungu and Brewer. |
First Published: | First published in Frontiers in Immunology 11:1597 |
Publisher Policy: | Reproduced under a Creative Commons license |
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